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Table 1 Relationship between clinicopathological features and tumor biomarkers in ESCC

From: Clinical use of tumor biomarkers in prediction for prognosis and chemotherapeutic effect in esophageal squamous cell carcinoma

Variable CA19–9 (U/ml) CA72–4 (U/ml) CEA (ug/L) Cyfra21–1 (ng/ml) SCC-Ag (ng/ml)
< 37(%) ≥37(%) p < 6(%) ≥6(%) p < 5(%) ≥5(%) p < 3.4(%) ≥3.4(%) p < 1.5(%) ≥1.5(%) p
Age(y)    0.613    0.806    0.010    0.013    0.215
  < 60 187 (46.6) 6 (40.0)   177 (46.6) 16 (44.4)   190 (47.7) 3 (16.7)   157 (49.8) 36 (35.6)   156 (48.0) 37 (40.7)  
  ≥ 60 214 (53.4) 9 (60.0)   203 (53.4) 20 (55.6)   208 (52.3) 15 (83.3)   158 (50.2) 65 (64.4)   169 (52.0) 54 (59.3)  
Gender    0.507    0.606    0.721    0.271    0.349
 Male 322 (80.3) 11 (73.3)   303 (79.7) 30 (83.3)   318 (79.9) 15 (83.3)   256 (81.3) 77 (76.2)   257 (79.1) 76 (83.5)  
 Female 79 (19.7) 4 (26.7)   77 (20.3) 6 (16.7)   80 (20.1) 3 (16.7)   59 (18.7) 24 (23.8)   68 (20.9) 15 (16.5)  
Tumor length    0.117    0.015    0.127    0.067    < 0.001
  < 4 161 (40.1) 3 (20.0)   143 (37.6) 21 (58.3)   160 (40.2) 4 (22.2)   132 (41.9) 32 (31.7)   143 (44.0) 21 (23.1)  
  ≥ 4 240 (59.9) 12 (80.0)   237 (62.4) 15 (41.7)   238 (59.8) 14 (77.8)   183 (58.1) 69 (68.3)   182 (56.0) 70 (76.9)  
Tumor location    0.842    0.461    0.930    0.594    0.369
 Upper 32 (8.0) 1 (6.7)   29 (7.6) 4 (11.1)   32 (8.0) 1 (5.6)   27 (8.6) 6 (5.9)   29 (8.9) 4 (4.4)  
 Middle 237 (59.1) 10 (66.7)   229 (60.3) 18 (50.0)   236 (59.3) 11 (61.1)   188 (59.7) 59 (58.4)   191 (58.8) 56 (61.5)  
 Lower 132 (32.9) 4 (26.7)   122 (32.1) 14 (38.9)   130 (32.7) 6 (33.3)   100 (31.7) 36 (35.6)   105 (32.3) 31 (34.1)  
Differentiation    0.555    0.634    0.372    0.299    0.050
Well-moderate 323 (80.5) 13 (86.7)   308 (81.1) 28 (77.8)   320 (80.4) 16 (88.9)   258 (81.9) 78 (77.2)   256 (78.8) 80 (87.9)  
 Poor 78 (19.5) 2 (13.3)   72 (18.9) 8 (22.2)   78 (19.6) 2 (11.1)   57 (18.1) 23 (22.8)   69 (21.2) 11 (12.1)  
pT category    0.475    0.679    0.467    0.355    0.051
 pT1 25 (6.2) 0 (0.0)   23 (6.1) 2 (5.6)   25 (6.3) 0 (0)   22 (7.0) 3 (3.0)   22 (6.8) 3 (3.3)  
 pT2 100 (24.9) 2 (13.3)   92 (24.2) 10 (27.8)   99 (24.9) 3 (16.7)   80 (25.4) 22 (21.8)   88 (27.1) 14 (15.4)  
 pT3 74 (18.5) 3 (20.0)   73 (19.2) 4 (11.1)   74 (18.6) 3 (16.7)   58 (18.4) 19 (18.8)   57 (17.5) 20 (22.0)  
 pT4 202 (50.4) 10 (66.7)   192 (50.5) 20 (55.6)   200 (50.3) 12 (66.7)   155 (49.2) 57 (56.4)   158 (48.6) 54 (59.3)  
pN category    0.280    0.443    0.001    0.007    < 0.001
 pN0 210 (52.4) 4 (26.7)   199 (52.4) 15 (41.7)   211 (53.0) 3 (16.7)   176 (55.9) 38 (37.6)   184 (56.6) 30 (33.0)  
 pN1 141 (35.2) 8 (53.3)   132 (34.7) 17 (47.2)   139 (34.9) 10 (55.6)   105 (33.3) 44 (43.6)   111 (34.2) 38 (41.8)  
 pN2 33 (8.2) 2 (13.3)   33 (8.7) 2 (5.6)   30 (7.5) 5 (27.8)   24 (7.6) 11 (10.9)   20 (6.2) 15 (16.5)  
 pN3 17 (4.2) 1 (6.7)   16 (4.2) 2 (5.6)   18 (4.5) 0 (0.0)   10 (3.2) 8 (7.9)   10 (3.1) 8 (8.8)  
TNM stage    0.361    0.773    0.075    0.070    < 0.001
 I 22 (5.5) 0 (0.0)   21 (5.5) 1 (2.8)   22 (5.5) 0 (0.0)   20 (6.3) 2 (2.0)   21 (6.5) 1 (1.1)  
 II 125 (31.2) 3 (20.0)   117 (30.8) 11 (30.6)   126 (31.7) 2 (11.1)   102 (32.4) 26 (25.7)   112 (34.5) 16 (17.6)  
 III 254 (63.3) 12 (80.0)   242 (63.7) 24 (66.7)   250 (62.8) 16 (88.9)   193 (61.3) 73 (72.3)   192 (59.1) 74 (81.3)  
PC    0.994    0.400    0.928    0.088    0.575
 Yes 241 (60.1) 9 (60.0)   226 (59.5) 24 (66.7)   239 (60.1) 11 (61.1)   182 (57.8) 68 (67.3)   193 (59.4) 57 (62.6)  
 No 160 (39.9) 6 (40.0)   154 (40.5) 12 (33.3)   159 (39.9) 7 (38.9)   133 (42.2) 33 (32.7)   132 (40.6) 34 (37.4)  
  1. Abbreviations: CA carbohydrate antigen, CEA carcinoembryonic antigen, ESCC esophageal squamous cell carcinoma, PC postoperative chemotherapy, SCC-Ag squamous cell carcinoma antigen