Characterization of molecular scores and gene expression signatures in primary breast cancer, local recurrences and brain metastases

Table 3 Allocation of molecular scores among PAM50 intrinsic subtypes

		lumA	lumB	Her2↑	basal
RISK	normal	< 0.01	0.17	0.01	0.02
	lumA		< 0.01	< 0.01	< 0.01
	lumB			< 0.01	< 0.01
	Her2↑				0.1
ROR-P	normal	0.05	< 0.01	< 0.01	< 0.01
	lumA		< 0.01	< 0.01	< 0.01
	lumB			< 0.01	< 0.01
	Her2↑				0.07
RS	normal	0.04	0.43	–	–
	lumA		< 0.01	–	–
	lumB			–	–
	Her2↑				–
EP	Normal	0.32	0.25	–	–
	lumA		< 0.01	–	–
	lumB			–	–
	Her2↑				–

RISK, and ROR-P were calculated from all 87 primary tumours, RS and EP from all 31 ER+/Her2- primary tumours as described. Scores were compared between any two groups using the Mann-Whitney test. Shown are p-values of all pairwise comparisons. Two-tailed p values > 0.05 were considered not significant.

ISSN: 1471-2407