Fig. 1

Hierarchical clustering of primary tumours, local recurrences and distant metastases. a The gene expression profile of all tumours was characterized by hierarchical clustering and the results are shown as a heatmap. Rows correspond to the 132 tumour samples and columns correspond to the 74 genes (which are part of RISK, RS, EP and/or PAM50). b The panel indicates for each sample whether it is a control (white), a primary tumour that later relapsed as local recurrence (grey) or a primary tumour that later progressed to a brain metastasis (black). The same colours are used for the local recurrences and brain metastases (grey and black, respectively). c Indicates the intrinsic subtype of each tumor: normal-like (ochre), lumA (light blue), lumB (blue), Her2↑ (pink) or basal (brown). d Indicates 19 pairs of primary tumours (P1 – P19) and local recurrences (R1 – R19). Pairs clustering in the vicinity of each other are highlighted with brackets. e. Indicates 19 pairs of primary tumours and brain metastases. Primary tumours and corresponding metastases are labeled P20 – P38 and M20 – M38, respectively. Pairs of tumors clustering in the vicinity of each other on the heatmap are depicted with brackets