The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis

BMC Cancer

Table 3 Summary Relative Risk (RR) Estimates [95% confidence intervals (CIs)] for Case–Control and Cohort Studies Conducted on the Association Between Diabetes and Endometrial Cancer Incidence by Study Design, Continent, and Age

Subgroup	Number of studies	Summery Relative Risk (95% CI)	Between studies			Between subgroups
Subgroup	Number of studies	Summery Relative Risk (95% CI)	I²	P _{heterogeneity}	Q	Q	P _{heterogeneity}
Study design
Cohort	8	1.52 (1.16–2.00)	70.7%	0.001	3.03	5.79	0.001^a
Case-Control	5	2.31 (1.81–2.96)	22.7%	0.270	6.69
Population-based	7	1.55 (1.37–1.75)	0.0%	0.461	6.88	4.95	0.034^b
Hospital-based	2	4.10 (2.09–8.01)	0.0%	0.402	4.12	4.95	0.034^b
Adjustment	3	1.88 (1.48–2.38)	81.9%	0.004	5.21	8.78	0.045
Age	13	1.62 (1.34–1.97)	71.0%	0.0001	4.14
BMI	3	2.45 (1.14–5.26)	21.0%	0.021	2.53
Weight	4	1.89 (1.22–2.94)	50.6%	0.108	6.08
Physical Activity

Largely diabetes mellitus
All statistical tests were 2-sided
^aTest for heterogeneity between case-control and cohort studies
^bTest for heterogeneity between population-based and hospital-based case-control studies

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