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Table 1 The Main Characteristics of Cohort and Population-based Cohort Studies on Diabetes and Endometrial Cancer Risk

From: The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis

Authors

Year

Type of study

Country

Study population

Age

Sample size

Type of diabetes

Measurement of association

Controlled variables

Al Hilli. M, et al. [16]

2015

Cohort

USA

database for the records of all patients who underwent primary surgical intervention for EC, from January 1, 1999, through December 31, 2008.

All age

1303

Diabetes

HR: 1.01; % 95 CI (0.72,1.42)

Age, BMI

Friberg. E, et al. [17]

2007

Cohort

Sweden

Exposed group: 1628 women with self-reported DM or DM from national inpatient register

Comparison group: 35145 women without self-reported DM or DM from national inpatient register

50–83

36,773

Diabetes

RR: 1.94; % 95 CI(1.23,3.08)

Age, BMI, total physical activity

Anderson. K, et al.[5]

2001

Cohort

USA

Exposed group: 1325 women with self-reported DM

Comparison group: 23150 women without self-reported DM

55–69

24,475

Diabetes

RR: 1.43; % 95 CI(0.98,2.09)

Age, BMI, BMI2, WHR, ovulatory span, gravidity, PMH, menstrual irregularities, hypertension

Lindemann. K, et al. [6]

2008

Cohort

Norway

Norwegian women during 15.7 years of follow-up.

All age

36,761

Diabetes

RR: 3.84 (% 95 CI: 1.92,5.11)

Age

Folsom. A, et al. [20]

2004

Cohort

USA

Exposed group: 42 women with self-reported DM and an endometrial cancer diagnosis

Comparison group: 373 women with self-reported DM and an endometrial cancer diagnosis

55–69

415

Diabetes

RR: 2.38 (% 95 CI: 1.05,5.37)

Age, extent of endometrial cancer at diagnosis

Luo. J, et al. [4]

2014

Cohort

USA

Women’s Health Initiative

50–79

88,107

Diabetes

HR: 1.16 (% 95 CI: 0.90,1.48)

Age, BMI

Terry. P, et al. [21]

1999

Cohort

Sweden

Exposed group: 142 women with self-reported DM

Comparison group: 10012 women without self-reported DM

42–81

10,154

Diabetes

RR: 1.60 (% 95 CI: 0.20,11.30)

Age, physical activity, weight, parity

Coughlin. S, et al. [19]

2004

Cohort

USA

Exposed group: 33 women with self-reported DM

Comparison group: 448 women without self-reported DM

> 30

481

Diabetes

RR: 1.33 (% 95 CI: 0.92,1.90)

Age, race, education, BMI, smoking, alcohol, red meat, citrus fruit and juice, vegetables, physical activity, PMH, parity, age at menarche, age at first live birth, menopausal status, OC

esLambe. M, et al. [18]

2011

Cohort

Sweden

individuals that took part in routine health checkups and primary care patients referred for laboratory testing

All age

230,737

Diabetes

HR: 1.46(% 95 CI 1.09,1.96

Age