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Fig. 3 | BMC Cancer

Fig. 3

From: Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma

Fig. 3

Prognostic power of core genes identified in Group 4. a, Kaplan-Meier curves and log-rank tests of the three groups stratified by Q1 (25% quantile) and Q3 (75% quantile) of the average expression of 31 core genes from top two PID pathways. b, Kaplan-Meier curve with log-rank test and boxplot of the average expression of 31 core genes of the two groups divided by the status of chr11 loss. c, Kaplan-Meier curve with log-rank test and boxplot of the average expression of 31 core genes of the two groups of 210 patients who do not harbor chr11 loss, stratified by the status of i(17q). d, Kaplan-Meier curve with log-rank test and boxplot of the average expression of 31 core genes of the two groups of 90 patients who do not harbor chr11 loss and i(17q), stratified by the status of 8q loss. e, Kaplan-Meier curve with log-rank test and boxplot of the average expression of 31 core genes of the two groups of 120 patients who harbor i(17q) but not chr11 loss, stratified by the presence of 10q loss, 1q gain, or 12q gain. f, Kaplan-Meier curve with log-rank test and boxplot of the average expression of 31 core genes of the three groups of 91 patients who harbor i(17q) but not chr11 loss, 10q loss, 1q gain, and 12q gain, stratified by the average expression of 31 core genes. g, Kaplan-Meier curve with log-rank test and boxplot of the average expression of 31 core genes of the three groups of 58 patients who do not harbor chr11 loss, i(17q), and 8q loss, stratified by the average expression of 31 core genes. h, Heatmap of expression of core genes from the fifteen prognostic canonical pathways with clinical information, prognostic chromosome aberrations, and subtype [9]. *, Mann–Whitney U test p-value < 0.05; **, p-value < 0.01; ***, p-value < 0.001

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