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Fig. 2 | BMC Cancer

Fig. 2

From: Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma

Fig. 2

Prognostic power of the core genes identified in Group 3. a, Kaplan-Meier curves and log-rank tests of the three groups stratified by Q1 (25% quantile) and Q3 (75% quantile) of the average expression of 20 core genes from top two PID pathways. b, Kaplan-Meier curve with log-rank test and boxplot of the average expression of 20 core genes of the three groups of 51 patients who harbor losses of 16p, 8q, or 4q, stratified by the number of simultaneous losses of 16p, 8q, and 4q. c, Kaplan-Meier curve with log-rank test and boxplot of the average expression of 20 core genes of the two groups of 56 patients who do not harbor losses of 16p, 8q, and 4q, stratified by status of i(17q) and simultaneous loss of 17p and 10q. d, Kaplan-Meier curve with log-rank test and boxplot of the average expression of 20 core genes of the two groups of 33 patients who do not harbor i(17q), simultaneous loss of 17p and 10q, and losses of 16p, 8q, and 4q, stratified by the average expression of 20 core genes. E, Heatmap of expression of core genes from the fifteen prognostic canonical pathways with clinical information, prognostic chromosome aberrations, and subtype [9]. *, Mann–Whitney U test p-value < 0.05; **, p-value < 0.01; ***, p-value < 0.001

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