Fig. 1

Prognostic power of core genes identified in SHH subgroup. a, Kaplan-Meier curves and log-rank tests of the three groups stratified by Q1 (25% quantile) and Q3 (75% quantile) of the average expression of 31 core genes from top two PID pathways. b, Kaplan-Meier curve with log-rank test and boxplot of the average expression of 31 core genes of the two groups divided by the status of 9p gain. c, Kaplan-Meier curve with log-rank test and boxplot of the average expression of 31 core genes of the three groups of 26 patients who harbor i(17q) or losses of 10q, 14q, or 17p but not 9p gain, stratified by the status of i(17q) and losses of 10q, 14q, and 17p. d, Kaplan-Meier curve with log-rank test and boxplot of the average expression of 31 core genes of the two groups of 69 patients who do not harbor 9p gain, i(17q), and losses of 10q, 14q, or 17p, stratified by the average expression of 31 core genes. e, Heatmap of expression of core genes from the nine prognostic canonical pathways with clinical information, prognostic chromosome aberrations, and subtype [9]. ***, Mann–Whitney U test p-value < 0.001