Polymorphisms in the CCR5 promoter associated with cervical intraepithelial neoplasia in a Chinese Han population

Table 4 haplotype frequencies comparison among CIN, CC and control groups

Haplotypes^a	CO (freq.)	CIN (freq.)	CC (freq.)	CIN vs CO		CC vs CO		CIN vs CC
Haplotypes^a	CO (freq.)	CIN (freq.)	CC (freq.)	P*	OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)
H1: A T G T G C	690 (50.58%)	305 (45.39%)	464 (47.54%)	1.42E-03	0.731 (0.603~0.886)	0.060	0.847 (0.713~1.007)	0.157	1.159 (0.945~1.421)
H2: A G A C A T	282 (20.67%)	161 (23.95%)	217 (22.23%)	0.21	1.153 (0.923~1.441)	0.486	1.075 (0.877~1.316)	0.558	0.932 (0.737~1.179)
H3: G G A C A C	214 (15.69%)	134 (19.94%)	162 (16.60%)	0.042	1.284 (1.009~1.634)	0.635	1.056 (0.843~1.323)	0.133	0.822 (0.637~1.062)
H4: A G G T A C	44 (3.23%)	31 (4.61%)	50 (5.12%)	0.178	1.380 (0.862~2.210)	0.026	1.598 (1.056~2.418)	0.533	1.158 (0.730~1.836)

Abbreviations: CIN Cervical intraepithelial neoplasia, CC Cervical cancer, CO Control, vs Versus, OR Odds ratio, CI Confidence Interval, H Haplotype
^ahaplotype, constructed by rs2227010-rs1799987-rs1799988-rs2734648-rs1800023-rs1800024
*Significance threshold after Bonferroni correction for multiple comparisons is P < 0.008 (which was indicated in bold)

ISSN: 1471-2407