Table 3 Different inheritance model analysis among CIN, CC and control groups
Inheritance Model | CO (n = 682) | CIN (n = 336) | CC (n = 488) | CIN vs CO | CC vs CO | CIN vs CC | ||||
|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P* | OR (95% CI) | P | OR (95% CI) | P | |||||
rs2227010 | ||||||||||
Dominant | A/A | 466 (68.33%) | 205 (61.01%) | 327 (67.01%) | 1.379 (1.050–1.810) | 0.021 | 1.062 (0.829–1.362) | 0.634 | 0.770 (0.577–1.029) | 0.077 |
A/G-G/G | 216 (31.67%) | 131 (38.99%) | 161 (32.99%) | |||||||
Recessive | A/A-A/G | 654 (95.89%) | 325 (96.73%) | 464 (95.18%) | 0.791 (0.389–1.608) | 0.516 | 1.208 (0.691–2.111) | 0.506 | 1.528 (0.738–3.164) | 0.25 |
G/G | 28 (4.11%) | 11 (3.27%) | 24 (4.92%) | |||||||
rs2734648 | ||||||||||
Dominant | T/T | 203 (29.77%) | 96 (28.57%) | 139 (28.48%) | 1.059 (0.794–1.413) | 0.694 | 1.064 (0.824–1.375) | 0.635 | 1.004 (0.738–1.366) | 0.978 |
G/T-G/G | 479 (70.23%) | 240 (71.43%) | 349 (71.52%) | |||||||
Recessive | T/T-G/T | 539 (79.03%) | 227 (67.56%) | 357 (73.16%) | 1.810 (1.350–2.427) | 6.66E-05 | 1.383 (1.054–1.816) | 0.019 | 0.764 (0.564–1.035) | 0.082 |
G/G | 143 (20.97%) | 109 (32.44%) | 131 (26.84%) | |||||||
rs1799987 | ||||||||||
Dominant | G/G | 246 (36.07%) | 117 (34.82%) | 170 (34.84%) | 1.056 (0.803–1.388) | 0.696 | 1.055 (0.828–1.346) | 0.664 | 0.999 (0.747–1.338) | 0.997 |
A/G-A/A | 436 (63.93%) | 219 (65.18%) | 318 (65.16%) | |||||||
Recessive | G/G-A/G | 561 (82.26%) | 243 (72.32%) | 378 (77.46%) | 1.774 (1.302–2.418) | 2.5E-04 | 1.349 (1.010–1.802) | 0.042 | 0.760 (0.552–1.047) | 0.093 |
A/A | 121 (17.74%) | 93 (27.68%) | 110 (22.54%) | |||||||
rs1799988 | ||||||||||
Dominant | T/T | 232 (34.02%) | 112 (33.33%) | 169 (34.63%) | 1.031 (0.782–1.360) | 0.828 | 1 | 0.827 | 0.944 (0.704–1.266) | 0.699 |
C/T-C/C | 450 (65.98%) | 224 (66.67%) | 319 (65.37%) | 0.973 (0.762–1.243) | ||||||
Recessive | T/T-C/T | 553 (81.09%) | 245 (72.92%) | 392 (80.33%) | 1.592 (1.171–2.166) | 0.003 | 1 | 0.746 | 0.659 (0.475–0.915) | 0.013 |
C/C | 129 (18.91%) | 91 (27.08%) | 96 (19.67%) | 1.050 (0.782–1.409) | ||||||
rs1800023 | ||||||||||
Dominant | G/G | 207 (30.35%) | 96 (28.57%) | 143 (29.30%) | 1.089 (0.817–1.452) | 0.559 | 1 | 0.699 | 0.965 (0.710–1.311) | 0.82 |
A/G-A/A | 475 (69.65%) | 240 (71.43%) | 345 (70.70%) | 1.051 (0.815–1.356) | ||||||
Recessive | G/G-A/G | 535 (78.45%) | 231 (68.75%) | 361 (73.98%) | 1.654 (1.233–2.220) | 7.5E-04 | 1 | 0.075 | 0.774 (0.569–1.052) | 0.101 |
A/A | 147 (21.55%) | 105 (31.25%) | 127 (26.02%) | 1.280 (0.975–1.681) | ||||||
rs1800024 | ||||||||||
Dominant | C/C | 405 (59.38%) | 187 (55.65%) | 279 (57.17%) | 1.165 (0.895–1.517) | 0.257 | 1 | 0.449 | 0.940 (0.710–1.244) | 0.666 |
C/T-T/T | 277 (40.62%) | 149 (44.35%) | 209 (42.83%) | 1.095 (0.865–1.386) | ||||||
Recessive | C/C-C/T | 639 (93.70%) | 312 (92.86%) | 462 (94.67%) | 1.143 (0.681–1.918) | 0.612 | 1 | 0.484 | 0.732 (0.412–1.298) | 0.284 |
T/T | 43 (6.30%) | 24 (7.14%) | 26 (5.33%) | 0.836 (0.507–1.381) | ||||||