Fig. 4

Microscopic appearance and immunophenotypes of the tumour at the splenic hilum. (a-h): Formalin-fixed paraffin-embedded splenic tumour sections (a): A focal infiltration of lymphocytes, HE × 10. (b): Diffuse large centroblast-like cells with a round, oval or irregular nuclei, distinct nucleoli, and scant cytoplasm. Frequent mitoses were seen. HE × 400. (c-h) original magnification, × 400. (c): CD20; (d): MUM-1; (e): IgM (Insert × 1000); (f): IgG; (g): CD138; (h): Ki-67