Fig. 2

Spatial analysis of H. pylori CagA, by Getis Ord Gi* hot spot cluster analysis. Clusters with a higher relative number of cases with H. pylori CagA infection were identified, but only in association with the incident diffuse cancer clusters. CagA hotspots were detected using the Getis-Ord Gi* statistic (P value ≤0.001; range 0.0001–0.0010), as shown in Fig. 2. The H. pylori CagA hotspots was also observed with the SaTScan statistic (P-value < 0.0085) in the same area (not shown). This indicates that CagA may be a co-factor in the diffuse gastric cancer cluster area. CagA was randomly distributed among the diffuse cancers outside of the hotspot. CagA was also randomly distributed among the intestinal cancers in the hotspot area and in the western Honduras as a whole