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Fig. 8 | BMC Cancer

Fig. 8

From: Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

Fig. 8

E7-specific CD8 T cells appearance in TC-1 mice vaccinated with adjuvanted E7 SLP. On day 0, mice (n = 20 per group) were implanted s.c. (footpad) with 2e4 TC-1 cells and then vaccinated s.c. (base of tail) on day 14 with 3 μg E7 SLP + CpG in w/o emulsion or adjuvant alone. Three mice from each group were sacrificed at 5 time points between days 14–28 and spleen and tumor tissue analyzed by FACS for E7-dextramer+ CD8 T cells within a total CD8+ population (spleen) and b total CD45+ population (tumor). c Tumor tissue from an additional mouse per group was immunohistochemically stained for the presence of CD8 T cells. All images 40X. Scale bars = 25 μm

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BMC Cancer

ISSN: 1471-2407

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