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Table 2 The subgroup analyses for B-NHL with different HBV infection status: univariate and multivariate logistic regression analyses

From: Both chronic HBV infection and naturally acquired HBV immunity confer increased risks of B-cell non-Hodgkin lymphoma

Variable B-NHL (n = 2535) Control (n = 7004) Univariate Multivariate
No. % No. % OR 95% CI P AOR 95% CI P*
HBsAg positive
 HBsAg-, anti-HBs-, anti-HBc- 733 (28.9) 2876( 41.1) 1 reference   1 reference  
 HBsAg+, HBeAg+, anti-HBc+ 49 (1.9) 32 (0.5) 6.01 3.82–9.45 < 0.001 6.23 3.95–9.82 < 0.001
 HBsAg+, anti-HBe-, anti-HBc+ 225 (8.9) 208 (3.0) 4.24 3.46–5.21 < 0.001 4.37 3.55–5.37 < 0.001
 HBsAg+, anti-HBe+, anti-HBc+ 139 (5.5) 362 (5.2) 1.51 1.22–1.86 < 0.001 1.51 1.22–1.86 < 0.001
HBsAg negative (A)
 HBsAg-, anti-HBs-, anti-HBc- 733 (28.9) 2876 (41.1) 1 Reference   1 Reference  
 HBsAg-, anti-HBs+, anti-HBc+ 601 (23.7) 1091 (15.6) 2.16 1.90–2.46 < 0.001 2.25 1.96–2.57 < 0.001
 HBsAg-, anti-HBs+, anti-HBc- 460 (18.1) 1769 (25.3) 1.02 0.90–1.16 0.76 1.04 0.91–1.19 0.56
 HBsAg-, anti-HBs-, anti-HBc+ 309 (12.2) 654 (9.3) 1.85 1.58–2.17 < 0.001 1.88 1.60–2.21 < 0.001
HBsAg negative (B)
 HBsAg-, anti-HBs+, anti-HBc+ 601 (23.7) 1091 (15.6) 1 Reference   1 Reference  
 HBsAg-, anti-HBs-, anti-HBc- 733 (28.9) 2876 (41.1) 0.46 0.41–0.53 < 0.001 0.45 0.39–0.51 < 0.001
 HBsAg-, anti-HBs+, anti-HBc- 139 (5.5) 362 (5.2) 0.47 0.41–0.55 < 0.001 0.46 0.40–0.54 < 0.001
 HBsAg-, anti-HBs-, anti-HBc+ 225 (8.9) 208 (3.0) 0.86 0.73–1.02 0.07 0.84 0.71–0.99 0.04
  1. Abbreviations: NHL = non-Hodgkin lymphoma, OR = odds ratio, CI = confidence interval, AOR = adjusted odds ratio, HBsAg = hepatitis B surface antigen, Anti-HBs = hepatitis B surface antibody, Anti-HBc = hepatitis B core antibody. The multivariate logistic regression analyses were adjusted by age (as a continuous variable), sex and year of diagnosis. * Statistically significant at the 0.05 alpha level. A: regard HBsAg-, anti-HBs-, anti-HBc- subgroup as reference. B: regard HBsAg-, anti-HBs+, anti-HBc + subgroup as reference