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Table 1 Associations of NHL subgroups with HBsAg: univariate & multivariate logistic regression analyses

From: Both chronic HBV infection and naturally acquired HBV immunity confer increased risks of B-cell non-Hodgkin lymphoma

Group All HBsAg+ Univariable Multivariable
N No. % OR 95% CI *P AOR 95% CI P
Control 7004 614 (8.8) 1 Reference   1 Reference  
NHL 3502 523 (14.9) 1.83 1.61–2.07 < 0.001 1.83 1.61–2.07 < 0.001
B-NHL 2535 432 (17.0) 2.14 1.87–2.44 < 0.001 2.14 1.88–2.45 < 0.001
DLBCL 1224 231 (18.9) 2.42 2.05–2.86 < 0.001 2.45 2.07–2.89 < 0.001
BL 90 11 (12.2) 1.45 0.77–2.74 0.25 1.69 0.89–3.22 0.11
FL 253 42 (16.6) 2.07 1.47–2.91 < 0.001 2.13 1.52–3.01 < 0.001
MCL 105 14 (13.3) 1.60 0.91–2.83 0.11 1.53 0.86–2.70 0.15
MALT 314 47 (15.0) 1.83 1.33–2.53 < 0.001 1.89 1.37–2.60 < 0.001
LPL 30 2 (0.7) 0.74 0.18–3.13 0.74 0.74 0.18–3.13 0.69
PBLL 37 5 (13.5) 1.63 0.63–4.19 0.31 3.79 1.38–10.38 0.01
CLL/SLL 341 58 (17.0) 2.13 1.59–2.86 < 0.001 2.12 1.58–2.85 < 0.001
other B-NHL 141 22 (15.6) 1.92 1.21–3.06 0.01 1.99 1.25–3.16 0.004
T-NHL 967 91 (9.4) 1.08 0.86–1.36 0.51 1.11 0.88–1.40 0.40
NK/T 436 34 (7.8) 0.88 0.61–1.26 0.49 0.89 0.62–1.28 0.53
PTCL-unclassified 161 17 (10.6) 1.23 0.74–2.05 0.43 1.24 0.74–2.06 0.41
ALCL 73 10 (13.7) 1.65 0.84–3.24 0.14 2.07 1.05–4.11 0.04
PTLL 119 8 (6.7) 0.75 0.36–1.54 0.44 0.95 0.45–1.96 0.88
AITL 122 18 (14.8) 1.80 1.09–2.99 0.02 1.84 1.10–3.06 0.02
other T-NHL 56 4 (7.1) 0.80 0.29–2.22 0.67 0.80 0.29–2.23 0.67
  1. Abbreviations: HBV = hepatitis B virus, HBsAg = hepatitis B surface antigen, CI = confidence interval, DLBCL = diffuse large B-cell lymphoma, BL = Burkitt’s lymphoma, FL = follicular lymphoma, MCL = mantle cell lymphoma, MALT = marginal zone lymphoma, LPL = lymphoplasmacytic lymphoma, PBLL = precursor B lymphoblastic lymphoma, CLL/SLL = small lymphocytic lymphoma/chronic lymphocytic leukaemia, NK/T = NK/T-cell lymphoma, PTCL = peripheral T-cell lymphoma, ALCL = anaplastic large cell lymphoma, PTLL = precursor T lymphoblastic lymphoma, AITL = angioimmunoblastic T-cell lymphoma, OR = odds ratio, AOR = adjusted odds ratio. The results were adjusted by age (as a continuous variable), sex and year of diagnosis. * Statistically significant at the 0.05 alpha level