Both chronic HBV infection and naturally acquired HBV immunity confer increased risks of B-cell non-Hodgkin lymphoma

Table 1 Associations of NHL subgroups with HBsAg: univariate & multivariate logistic regression analyses

Group	All	HBsAg+	Univariable			Multivariable
Group	N	No. %	OR	95% CI	*P	AOR	95% CI	P
Control	7004	614 (8.8)	1	Reference		1	Reference
NHL	3502	523 (14.9)	1.83	1.61–2.07	< 0.001	1.83	1.61–2.07	< 0.001
B-NHL	2535	432 (17.0)	2.14	1.87–2.44	< 0.001	2.14	1.88–2.45	< 0.001
DLBCL	1224	231 (18.9)	2.42	2.05–2.86	< 0.001	2.45	2.07–2.89	< 0.001
BL	90	11 (12.2)	1.45	0.77–2.74	0.25	1.69	0.89–3.22	0.11
FL	253	42 (16.6)	2.07	1.47–2.91	< 0.001	2.13	1.52–3.01	< 0.001
MCL	105	14 (13.3)	1.60	0.91–2.83	0.11	1.53	0.86–2.70	0.15
MALT	314	47 (15.0)	1.83	1.33–2.53	< 0.001	1.89	1.37–2.60	< 0.001
LPL	30	2 (0.7)	0.74	0.18–3.13	0.74	0.74	0.18–3.13	0.69
PBLL	37	5 (13.5)	1.63	0.63–4.19	0.31	3.79	1.38–10.38	0.01
CLL/SLL	341	58 (17.0)	2.13	1.59–2.86	< 0.001	2.12	1.58–2.85	< 0.001
other B-NHL	141	22 (15.6)	1.92	1.21–3.06	0.01	1.99	1.25–3.16	0.004
T-NHL	967	91 (9.4)	1.08	0.86–1.36	0.51	1.11	0.88–1.40	0.40
NK/T	436	34 (7.8)	0.88	0.61–1.26	0.49	0.89	0.62–1.28	0.53
PTCL-unclassified	161	17 (10.6)	1.23	0.74–2.05	0.43	1.24	0.74–2.06	0.41
ALCL	73	10 (13.7)	1.65	0.84–3.24	0.14	2.07	1.05–4.11	0.04
PTLL	119	8 (6.7)	0.75	0.36–1.54	0.44	0.95	0.45–1.96	0.88
AITL	122	18 (14.8)	1.80	1.09–2.99	0.02	1.84	1.10–3.06	0.02
other T-NHL	56	4 (7.1)	0.80	0.29–2.22	0.67	0.80	0.29–2.23	0.67

Abbreviations: HBV = hepatitis B virus, HBsAg = hepatitis B surface antigen, CI = confidence interval, DLBCL = diffuse large B-cell lymphoma, BL = Burkitt’s lymphoma, FL = follicular lymphoma, MCL = mantle cell lymphoma, MALT = marginal zone lymphoma, LPL = lymphoplasmacytic lymphoma, PBLL = precursor B lymphoblastic lymphoma, CLL/SLL = small lymphocytic lymphoma/chronic lymphocytic leukaemia, NK/T = NK/T-cell lymphoma, PTCL = peripheral T-cell lymphoma, ALCL = anaplastic large cell lymphoma, PTLL = precursor T lymphoblastic lymphoma, AITL = angioimmunoblastic T-cell lymphoma, OR = odds ratio, AOR = adjusted odds ratio. The results were adjusted by age (as a continuous variable), sex and year of diagnosis. * Statistically significant at the 0.05 alpha level

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