Category/treatment | N | 5-year CI | 10-year CI | p-value | |||
---|---|---|---|---|---|---|---|
PE | 95% CI | PE | 95% CI | ||||
Overall | 5311 | 5.4 | [4.8, 6.0] | 7.8 | [7.0, 8.6] | ||
Age | < 70 years | 3714 | 5.7 | [5.0, 6.5] | 8.5 | [7.6, 9.5] | 0.007 |
≥ 70 years | 1597 | 4.5 | [3.6, 5.6] | 6.1 | [4.9, 7.4] | ||
Clinical stage | T1/2N0 | 2918 | 2.8 | [2.3, 3.5] | 5.1 | [4.3, 6.1] | < 0.001 |
T1/2N+ | 1613 | 7.3 | [6.1, 8.7] | 10.3 | [8.8, 12.0] | ||
T3/4N0 | 124 | 8.9 | [5.0, 15.7] | 13.0 | [8.0, 21.1] | ||
T3/4N+ | 409 | 13.9 | [10.9, 17.7] | 15.1 | [12.0, 19.0] | ||
missing | 247 | 6.9 | [4.4, 11.0] | 7.8 | [5.1, 12.1] | ||
Morphology | invasive ductal | 3690 | 5.7 | [5.0, 6.5] | 8.1 | [7.2, 9.1] | 0.395 |
invasive lobular | 758 | 4.5 | [3.2, 6.3] | 8.0 | [6.2, 10.5] | ||
mixed type | 459 | 4.1 | [2.7, 6.4] | 6.0 | [4.1, 8.7] | ||
other | 404 | 5.5 | [3.7, 8.3] | 6.5 | [4.4, 9.5] | ||
Histopathologic grade | 1 | 447 | 1.3 | [0.6, 3.0] | 3.3 | [1.9, 5.9] | < 0.001 |
2 | 3332 | 4.3 | [3.6, 5.0] | 6.6 | [5.8, 7.6] | ||
3/4 | 1497 | 8.8 | [7.5, 10.3] | 11.4 | [9.9, 13.3] | ||
missing | 35 | 11.4 | [4.5, 29.2] | 15.5 | [6.7, 36.0] | ||
HR expression | positivea | 4132 | 4.1 | [3.6, 4.8] | 6.6 | [5.8, 7.4] | < 0.001 |
negative | 775 | 12.4 | [10.3, 15.0] | 15.2 | [12.8, 18.1] | ||
missing | 404 | 4.2 | [2.7, 6.8] | 5.2 | [3.4, 8.0] | ||
HER2/neu expression | positiveb | 972 | 7.1 | [5.7, 8.9] | 10.8 | [8.8, 13.2] | 0.004 |
negative | 2941 | 4.9 | [4.2, 5.7] | 6.9 | [6.0, 8.0] | ||
missing | 1398 | 5.1 | [4.1, 6.4] | 7.6 | [6.3, 9.2] | ||
Subtype based on immunohistochemical surrogates | ‘HR positive‘ | 4132 | 4.1 | [3.6, 4.8] | 6.6 | [5.8, 7.4] | < 0.001 |
‚HER2/neu positive‘c | 234 | 12.9 | [9.2, 18.0] | 16.2 | [11.8, 22.3] | ||
‘triple negative‘d | 376 | 12.0 | [9.1, 15.8] | 13.8 | [10.6, 17.9] | ||
missing | 569 | 6.7 | [4.9, 9.1] | 9.1 | [6.9, 11.9] | ||
BCS | T1/2N0 | 198 | 3.6 | [1.7, 7.4] | 4.9 | [2.3, 10.2] | |
BCS + RT | T1/2N0 | 2114 | 2.1 | [1.6, 2.9] | 4.4 | [3.5, 5.5] | |
Mastectomy | T1/2N0 | 606 | 4.8 | [3.4, 6.9] | 7.9 | [5.9, 10.5] | |
(BCS + RT or mastectomy) + HT | T1/2N0 HR positive a | 1749 | 1.7 | [1.2, 2.4] | 4.3 | [3.3, 5.5] | |
(BCS + RT or mastectomy) + CT | T1/2N0 HR negative | 277 | 6.5 | [4.2, 10.2] | 9.3 | [6.3, 13.7] | |
(BCS + RT or mastectomy) + HT (if HR positive) + CT (if HR negative) + TT | T1/2N0 HER2/neu positive | 73 | 0.0 | – | 0.0 | – | |
(BCS or mastectomy) + RT + CT + HT | T1/2N+ HR positive a | 554 | 5.8 | [4.2, 8.2] | 8.3 | [6.2, 11.2] | |
(BCS or mastectomy) + RT + CT | T1/2N+ HR negative | 156 | 12.9 | [8.5, 19.4] | 16.5 | [11.3, 24.1] | |
(BCS or mastectomy) + RT + CT + HT (if HR positive) + TT | T1/2N+ HER2/neu positive | 51 | 9.8 | [4.2, 22,7] | 9.8 | [4.2, 22,7] | |
MAST + RT + CT + HT | T3/4 HR positive a | 88 | 17.0 | [10.7, 27.1] | 17.0 | [10.7, 27.1] | |
MAST + RT + CT | T3/4 HR negative | 50 | 22.0 | [13.0, 37.3] | 26.2 | [16.3, 42.1] |