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Table 3 Univariable and multivariable analysis of training set for OS

From: Development and validation of nomograms predicting survival in Chinese patients with triple negative breast cancer

 

Univariable an- alysis P

Multivariable analysis

Selected factors for building the nomogram

Variable

HR

95% CI

P

HR

95% CI

P

Grade

0.032

      

 I

 

Ref

     

 II

 

0.151

0.014–1.605

0.117

   

 III

 

0.461

0.055–3.876

0.476

   

Tumor size

<0.001

      

 ≤2 cm

 

Ref

  

Ref

  

 2-5 cm

 

3.226

1.541–6.755

0.002

2.981

1.516–5.864

0.002

 >5 cm

 

4.704

1.587–13.939

0.005

4.916

1.705–14.174

0.003

Node status

<0.001

      

 N0

 

Ref

  

Ref

  

 N1

 

2.121

0.941–4.778

0.070

2.183

1.050–4.559

0.037

 N2 + N3

 

4.545

2.086–9.902

<0.001

4.900

2.328–10.312

<0.001

Ki67 index

0.018

      

 <40%

 

Ref

  

Ref

  

 ≥40%

 

2.778

1.339–5.763

0.006

2.906

1.440–5.863

0.003

sTIL group (%)

0.025

      

 0–9

 

Ref

  

Ref

  

 10–19

 

0.578

0.269–1.240

0.159

0.523

0.252–1.085

0.082

 20–49

 

0.272

0.108–0.686

0.006

0.320

0.134–0.767

0.011

 ≥50

 

0.217

0.075–0.629

0.005

0.230

0.082–0.645

0.005

Surgery type

0.198

      

 Mastectomy

       

 Lumpectomy

       

Radiotherapy

0.315

      

 Yes

       

 No

       

Age

0.392

      

 ≤35

       

 36–50

       

 >50

       

Marital status

0.588

      

 Married

       

 Unmarried

       

Family history of breast cancer

0.274

      

 Yes

       

 No

       

Menopausal status

0.107

      

 Premenopausal

       

 Postmenopausal

       

Histology

0.224

      

 Ductal

       

 Lobular/other

       

Chemotherapy type

0.374

      

 Neoadjuvant

       

 Adjuvant

       

 No chemotherapy

       

Chemotherapy regimen

0.046

      

 anthracycline-based

 

Ref

     

 taxane-based

 

1.551

0.682–3.528

0.296

   

 anthracycline& taxane -based

 

0.781

0.371–1.643

0.514

   
  1. Abbreviations: OS overall survival, HR hazard ratio, CI confidence interval, Ref reference, sTIL stromal tumor-infiltrating lymphocyte