Fig. 5
From: Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor
The in vivo anti-tumor effects of PB221 against ALTS1C1 tumors. (a) The tumor growth curves of intramuscular ALTS1C1 tumors following the treatment of PB221 and TMZ. One dose of TMZ (2 mg/mouse/injection) and 4 doses of PB221 (2 mg/mouse/injection) were intraperitoneally injected into tumor-bearing mice at day 10 following the tumor inoculation as indicated by the arrows in the graph. The data represented the average tumor volume in each group from one representative experiment of three independent experiments. *: P < 0.05. **: P < 0.01. ***: P < 0.001. (b) The change of mouse body weight following the intramuscular tumor implantation and the treatment of 4 doses of PB221 (2 mg/mouse/injection) and one dose of TMZ (2 mg/mouse/injection). *: P < 0.05. (c) The animal survival curve for mouse-bearing intracranial ALTS1C1 tumor and the treatment of 5 doses of PB221 (1 mg/mouse/injection) and one dose of TMZ (2 mg/mouse/injection). **: P < 0.01; ****: P < 0.0001. (d) The change of mouse body weight following the intracranial tumor inoculation and the treatment of 5 doses of PB221 (1 mg/mouse/injection) and one dose of TMZ (2 mg/mouse/injection). *: P < 0.05. **: P < 0.01