Skip to main content

Table 4 The effect of subsequent radiotherapy and/or chemotherapy on the risk of developing thyroid disorders in head and neck cancer patients

From: Subsequent thyroid disorders associated with treatment strategy in head and neck cancer patients: a nationwide cohort study

  PTE + ND PTE
Non-RT & Non-CT
(N = 5319)
RT only
(N = 597)
CT only
(N = 251)
CCRT
(N = 1133)
Sequential CT + RT
(N = 160)
Non-RT, Non-CT
(N = 3079)
RT only
(N = 264)
CT only
(N = 122)
CCRT
(N = 239)
Sequential CT + RT
(N = 26)
N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%)
Thyroid disorders 71 (1.33) 25 (4.19) 2 (1.64) 22 (1.94) 2 (1.25) 41 (1.33) 5 (1.89) 0 (0.00) 4 (1.67) 0 (0.00)
Crude HR 1 3.70 (2.34–5.83)* 0.58 (0.14–2.35) 1.75 (1.08–2.82)* 1.10 (0.27–4.47) 1 1.47 (0.58–3.71) 1.47 (0.53–4.12)
Adjusted HR 1 3.64 (2.28–5.81)* 0.58 (0.14–2.36) 1.70 (1.05–2.77)* 1.01 (0.25–4.14) 1 1.41 (0.56–3.58) 1.51 (0.54–4.23)
CRR 1 3.00 (1.89–4.77)* 0.49 (0.12–2.02) 1.19 (0.74–1.93) 0.73 (0.18–2.98) 1 1.21 (0.48–3.05) 1.09 (0.38–3.11)
  1. PTE primary tumor excision, ND neck dissection, RT radiotherapy, Non-RT non-radiotherapy, CT chemotherapy, Non-CT non-chemotherapy, CCRT concomitant chemoradiation therapy, HR hazard ratio, CRR competing risk regression
  2. *P < 0.05