| Unit | 0.2 g/kg(n = 3) | 0.4 g/kg(n = 3) | 0.6 g/kg(n = 3) | 0.8 g/kg(n = 3) | 1 g/kg(n = 2) | 1.2 g/kg(n = 3) | 1.5 g/kg(n = 3) |
---|---|---|---|---|---|---|---|---|
D1 | Cmax (mmol/l) | 4.2 ± 3.9 | 5.1 ± 1.1 | 7.4 ± 1.2 | 12.1 ± 5.7 | 14.0 ± 3.9 | 16.4 ± 2.5 | 17.4 ± 7.2 |
t1/2(h) | 3.1 ± 1.2 | 1.8 ± 0.6 | 2.0 ± 0.2 | 1.9 ± 0.05 | 1.5 ± 0.2 | 1.4 ± 0.09 | 1.97 ± 0.8 | |
AUC (mmol/l *h) | 21.0 ± 18.0 | 22.5 ± 8.8 | 31.5 ± 3.0 | 49.0 ± 15.8 | 55.3 ± 2.3 | 73.3 ± 12.3 | 82.3 ± 43.3 | |
Vz (ml) | 15.3 ± 5.6 | 13.6 ± 1.7 | 14.2 ± 3.8 | 14.2 ± 2.4 | 12.7 ± 1.6 | 11.5 ± 1.3 | 14.9 ± 4.0 | |
Cl (ml/h) | 4.1 ± 2.5 | 5.8 ± 2.9 | 4.9 ± 1.4 | 5.1 ± 1.0 | 6.0 ± 0.03 | 5.5 ± 0.4 | 5.5 ± 1.7 | |
D3 | Cmax (mmol/l) | 3.5 ± 1.7 | 3.7 ± 0.9 | 7.2 ± 1.1 | 11.2 ± 3.3 | 9.5 ± 3.0 | 16.5 ± 1.5 | 17.8 ± 5.5 |
t1/2(h) | 1.9 ± 0.8 | 2.4 ± 0.9 | 1.7 ± 0.4 | 1.6 ± 0.1 | 1.5 ± 0.2 | 1.5 ± 0.06 | 1.98 ± 0.6 | |
AUC (mmol/l *h) | 14.9 ± 7.4 | 19.0 ± 7.5 | 34.1 ± 3.9 | 54.8 ± 16.1 | 35.4 ± 15.8 | 65.5 ± 8.0 | 89.5 ± 52.4 | |
Vz (ml) | 12.2 ± 7.6 | 21.4 ± 3.2 | 10.6 ± 3.6 | 10.9 ± 2.7 | 22.6 ± 7.7 | 13.3 ± 3.4 | 14.2 ± 3.6 | |
Cl (ml/h) | 4.4 ± 1.8 | 6.9 ± 3.5 | 4.4 ± 0.6 | 4.6 ± 1.0 | 10.5 ± 5.0 | 6.2 ± 1.4 | 5.3 ± 2.1 |