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Fig. 3 | BMC Cancer

Fig. 3

From: An image-based assay to quantify changes in proliferation and viability upon drug treatment in 3D microenvironments

Fig. 3

Replication of microenvironmental effects using cells from PDX tumors. Plots show aggregate viability (a & b) and proliferation (c & d) scores for PDX1, a BRaf V600E mutant melanoma, and PDX2, a BRaf WT melanoma, normalized to DMSO controls, cultured either in 2D dishes or 3D collagen cultures and treated with RMIC treatments as in Fig. 2. Data are shown for three independent experimental repeats as average ± SEM (** p < 0.0005, *** p < 0.00005)

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