Vitronectin as a molecular player of the tumor microenvironment in neuroblastoma

BMC Cancer

Table 2 p-values and relationship between vitronectin and nuclei morphometric measurements and poor prognostic factors

Parameter			Age: ≥18 months	Stage: M	Hist.D: uNB/pdNB	MYCN: MNA	Gen. profile: SCA	11q: 11qD	Risk group: high-risk	Gen. Instab.:High
IPP	Nuclei	Dens.	–	0.005↑	0.007↑	0.001↑	–	–	0.001↑	0.003↑
	Nuclei	%SA	0.004↑	–	–	–	0.018↓	–	–	–
	Inter.VN	%SA	–	–	–	–	–	–	–	–
	Terr.VN	%SA	–	0.010↑	0.001↑*	0.024↑	0.001↑	0.035↑	0.008↑	0.000↑
Densito	VN ratio of pixels	Weak	–	–	–	–	–	–	–	–
		Mod.	–	–	–	–	–	–	–	–
		Strong	–	0.037↑	0.010↑*	0.011↑	0.002↑	0.021↑	0.004↑	0.010 ↑
	H-score		–	–	0.019↑	0.040↑	0.011↑	–	0.008↑	0.001↑

Only morphometric variables for vitronectin (VN) expression and nuclei having a statistically significant relationship with pre-treatment risk stratification factors are shown (p-value< 0.05). IPP: Image Pro-Plus; Densito: DensitoQuant; Dens. Density (number of objects/mm2); %SA: percentage of stained area; Inter. VN: Interterritorial VN; Terr.VN: Territorial VN; Mod.: moderate. M: metastatic; Hist.D: histopathologic differentiation; uNB: undifferentiated neuroblastoma; pdNB: poorly differentiated neuroblastoma; NOS was excluded from statistical analysis; Gen. Profile: genetic profile; SCA: segmental chromosomal aberration; MNA: MYCN amplified; 11qD: 11q deletion; Gen. Instab.: genetic instability. -: not statistically significant, ↑/↓: higher or lower median value for the poor-prognostic group(s). *There are statistically significant differences between pdNB and uNB, within Strong VN (p-value< 0.05) and %SA Territorial VN (p-value< 0.1) morphometric variables

ISSN: 1471-2407