TY - JOUR AU - Jiang, Feng AU - Yu, Wei AU - Zeng, Fanrui AU - Cheng, Guoping AU - Xu, Jing AU - Yang, Shifeng AU - Shui, Yongjie AU - Wu, Dang AU - Yu, Xiao-fang AU - Wei, Qichun PY - 2019 DA - 2019/05/28 TI - PD-1 high expression predicts lower local disease control in stage IV M0 nasopharyngeal carcinoma JO - BMC Cancer SP - 503 VL - 19 IS - 1 AB - Tumor-infiltrating lymphocytes (TILs) play a critical role in tumor immune surveillance and immune suppression. Understanding tumor infiltrating T cell subset density, location and PD-1/PD-L1 expression might provide insight for the prediction of tumor therapeutic response and clinical outcome. The purpose of this study was to evaluate the expression and localization of CD8, FoxP3, PD-1, and PD-L1 in primary tumor tissues and their effects on prognosis of stage IV M0 locally advanced nasopharyngeal carcinoma (NPC) patients. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-019-5689-y DO - 10.1186/s12885-019-5689-y ID - Jiang2019 ER -