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Table 4 Univariate and multivariate Cox proportional hazards analyses of MMP19 expression and disease free survival for patients with colorectal cancer in the validation cohort

From: High expression of MMP19 is associated with poor prognosis in patients with colorectal cancer

Factor

Univariate analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

Gender

0.924(0.541–1.578)

0.772

  

Age

1.327(0.790–2.227)

0.285

  

T category

2.044(1.263–3.307)

0.004

1.527(0.972–2.400)

0.066

N stage

1.784 (1.285–2.457)

0.001

1.642(1.140–2.365)

0.008

Tumor location

0.902(0.539–1.509)

0.694

  

Histologic type

0.900(0.282–2.878)

0.860

  

Grade

1.200(0.831-1.733)

0.330

  

Intramural vascular invasion

2.190(1.264–3.796)

0.005

1.337(0.754–2.371)

0.321

Perineural invasion

1.965(1.076–3.588)

0.028

1.393(0.738–2.628)

0.306

MMP19

4.909(2.598–9.275)

< 0.001

4.699(2.461–8.974)

< 0.001

  1. Abbreviations: CI confidence interval, HR hazard ratio, MMP19 matrix metalloproteinase 19, T tumor, N node
  2. Bold type indicates statistical significance