Fig. 1From: Combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful vertebral metastases - a randomized phase III studyTrial Workflow. *study centers may choose between fractionated EBRT (30 Gy in 10 fractions) or single-dose EBRT (1 × 8 Gy). Once an option is chosen, the center must adhere to it for all patients included into the trial. Legend: IORT- intraoperative radiotherapy; Kypho-IORT – kyphoplasty or vertebroplasty + IORT; EBRT – external beam radiotherapyBack to article page