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Fig. 2 | BMC Cancer

Fig. 2

From: Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway

Fig. 2

Knockdown of MVP accelerates xenografted LLC tumor growth in mice. LLC cells were infected by the lenti-shRNA against MVP for 24 h. After selection by puromycin for at least 2 weeks, the stably transfected LLC cells were subcutaneously injected into C57BL/6 mice. Three weeks later the tumor tissues were isolated for measurements. a Western blot analysis of MVP in the transfected LLC cells. b Quantification of MVP expression in the transfected LLC cells. (n = 3, * P < 0.05). c Images of xenografted tumors isolated from the mice. d, e Quantification of volume and weight of the xenografted tumors. (shRNA-N, n = 14; shRNA-MVP1, n = 16; shRNA-MVP2, n = 17, * P < 0.05) f. Representative IHC staining of Ki67 and CD31 in mouse tumor tissues. g, h Quantification of the IHC staining (n = 7, ** P < 0.05)

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