Characteristica | MIILE (n = 92) | Sweet (n = 94) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Baseline | 3 months | 6 months | 12 months | 24 months | Baseline | 3 months | 6 months | 12 months | 24 months | |
EORTC C30b | ||||||||||
 Global health | 73.53 ± 11.19 | 65.82 ± 11.54*/** | 69.29 ± 12.38*/** | 72.69 ± 15.98* | 74.02 ± 16.49 | 75.89 ± 16.06 | 49.32 ± 10.01** | 57.13 ± 14.89** | 62.63 ± 10.37** | 71.81 ± 15.19 |
Functioning scales | ||||||||||
 Physical functioning | 84.89(73.03–93.24) | 66.94 ± 10.47*/** | 73.57 ± 12.61*/** | 81.34(70.61–89.29) */** | 84.40 ± 10.18* | 84.00(76.12–93.64) | 50.20 ± 8.45** | 48.69 ± 12.38** | 72.58 ± 12.50** | 73.08 ± 14.74** |
 Role functioning | 82.31(73.63–90.02) | 61.64 ± 10.80*/** | 71.18 ± 8.08*/** | 80.88 ± 8.59* | 81.21 ± 10.02 | 79.16 ± 11.16 | 54.56 ± 1.38** | 59.72 ± 8.67** | 75.96 ± 12.51 | 81.48 ± 9.22 |
 Emotional functioning | 70.06 ± 11.78 | 73.30 ± 11.97* | 77.81 ± 11.18*/** | 78.62 ± 10.46** | 81.58 ± 11.3** | 70.00 ± 8.20 | 63.19 ± 10.76** | 69.74 ± 7.29 | 79.98(71.25–90.41)** | 79.38 ± 9.91** |
Symptom scales | ||||||||||
 Fatigue | 21.46 ± 11.55 | 44.16 ± 9.26*/** | 36.14 ± 18.23*/** | 27.97 ± 6.47*/** | 23.15 ± 12.33 | 21.40 ± 11.49 | 59.19 ± 10.26** | 49.14 ± 12.93** | 31.78 ± 13.40** | 26.23 ± 14.40** |
 Pain | 19.54 ± 9.46 | 32.62(23.79–39.34) */** | 30.09 ± 7.76*/** | 26.83 ± 6.31*/** | 24.58 ± 9.12** | 18.78 ± 7.49 | 56.15 ± 1.61** | 40.88 ± 12.56** | 30.29 ± 10.48** | 25.74 ± 5.36** |
 Dyspnea | 12.47 ± 6.63 | 26.78 ± 9.31*/** | 22.06 ± 7.64*/** | 16.11 ± 9.65** | 14.10 ± 6.50 | 12.80 ± 7.19 | 32.36 ± 10.91** | 25.00 ± 8.33** | 17.63 ± 5.68** | 14.12 ± 6.52 |
 Insomnia | 22.06 ± 9.97 | 34.68 ± 10.55*/** | 29.77 ± 7.99*/** | 25.81 ± 10.21*/** | 21.97 ± 10.97 | 24.24 ± 10.61 | 41.88 ± 12.90** | 39.40 ± 11.96** | 29.19 ± 9.47** | 21.45 ± 12.74 |
 Appetite loss | 36.01 ± 12.24 | 22.81 ± 12.74*/** | 22.81 ± 13.07** | 17.91 ± 9.43*/** | 19.45 ± 8.78** | 31.80 ± 19.17 | 27.06 ± 10.95** | 23.99 ± 13.41** | 22.33 ± 11.28** | 21.07 ± 8.79** |
 Constipation | 22.11 ± 13.20 | 17.87 ± 11.58*/** | 16.03(9.37–28.83) | 17.44 ± 1.23** | 16.20 ± 7.81** | 17.40(8.39–26.69) | 22.64 ± 12.1** | 21.46(7.65–32.99) | 18.88 ± 8.06 | 17.94 ± 9.23 |
EORTC OES 18 | ||||||||||
 Dysphagia | 39.26 ± 17.21 | 26.15 ± 13.22** | 23.80 ± 12.06** | 22.66 ± 11.98** | 17.29 ± 7.39** | 39.86 ± 10.03 | 27.55 ± 15.03** | 26.43 ± 12.16** | 23.02 ± 12.56** | 18.09 ± 8.73** |
 Eating | 39.57 ± 11.90 | 36.63(31.88–42.97) ** | 32.12 ± 10.29** | 24.66 ± 10.70** | 22.81 ± 8.38** | 39.00 ± 11.55 | 34.41 ± 11.57** | 29.27 ± 14.67** | 25.69 ± 12.28** | 22.15 ± 9.75** |
 Reflux | 21.67 ± 10.37 | 37.58 ± 12.41** | 33.31 ± 16.21** | 32.05 ± 13.96** | 29.57 ± 10.20** | 22.23 ± 11.59 | 37.74 ± 17.40** | 33.16 ± 15.51** | 33.06 ± 13.78** | 31.79 ± 15.02** |
 Pain | 16.55 ± 11.47 | 25.02 ± 10.00*/** | 14.21 ± 7.93* | 12.56 ± 7.12* | 11.92 ± 6.14 | 18.24 ± 10.33 | 28.13 ± 10.80** | 25.49 ± 11.92** | 15.50 ± 9.48 | 12.27 ± 7.20** |
 Choking | 31.97 ± 14.17 | 23.08 ± 10.24** | 22.87 ± 13.60** | 21.60 ± 10.92*/** | 21.17 ± 12.78** | 31.33 ± 12.18 | 20.36 ± 12.74** | 25.42 ± 14.50** | 25.11 ± 9.80** | 20.06 ± 10.48** |
 Coughing | 12.03(6.94–20.54) | 27.51 ± 11.64** | 25.96 ± 8.67** | 21.52 ± 9.58** | 19.93 ± 8.49** | 14.32(4.79–22.67) | 28.11 ± 14.80** | 24.97 ± 8.07** | 20.71 ± 8.37** | 22.19 ± 10.64** |