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Table 5 Quality of Life After Surgery

From: Comparison of minimally invasive Ivor Lewis esophagectomy and left transthoracic esophagectomy in esophageal squamous cell carcinoma patients: a propensity score-matched analysis

Characteristica MIILE (n = 92) Sweet (n = 94)
Baseline 3 months 6 months 12 months 24 months Baseline 3 months 6 months 12 months 24 months
EORTC C30b
 Global health 73.53 ± 11.19 65.82 ± 11.54*/** 69.29 ± 12.38*/** 72.69 ± 15.98* 74.02 ± 16.49 75.89 ± 16.06 49.32 ± 10.01** 57.13 ± 14.89** 62.63 ± 10.37** 71.81 ± 15.19
Functioning scales
 Physical functioning 84.89(73.03–93.24) 66.94 ± 10.47*/** 73.57 ± 12.61*/** 81.34(70.61–89.29) */** 84.40 ± 10.18* 84.00(76.12–93.64) 50.20 ± 8.45** 48.69 ± 12.38** 72.58 ± 12.50** 73.08 ± 14.74**
 Role functioning 82.31(73.63–90.02) 61.64 ± 10.80*/** 71.18 ± 8.08*/** 80.88 ± 8.59* 81.21 ± 10.02 79.16 ± 11.16 54.56 ± 1.38** 59.72 ± 8.67** 75.96 ± 12.51 81.48 ± 9.22
 Emotional functioning 70.06 ± 11.78 73.30 ± 11.97* 77.81 ± 11.18*/** 78.62 ± 10.46** 81.58 ± 11.3** 70.00 ± 8.20 63.19 ± 10.76** 69.74 ± 7.29 79.98(71.25–90.41)** 79.38 ± 9.91**
Symptom scales
 Fatigue 21.46 ± 11.55 44.16 ± 9.26*/** 36.14 ± 18.23*/** 27.97 ± 6.47*/** 23.15 ± 12.33 21.40 ± 11.49 59.19 ± 10.26** 49.14 ± 12.93** 31.78 ± 13.40** 26.23 ± 14.40**
 Pain 19.54 ± 9.46 32.62(23.79–39.34) */** 30.09 ± 7.76*/** 26.83 ± 6.31*/** 24.58 ± 9.12** 18.78 ± 7.49 56.15 ± 1.61** 40.88 ± 12.56** 30.29 ± 10.48** 25.74 ± 5.36**
 Dyspnea 12.47 ± 6.63 26.78 ± 9.31*/** 22.06 ± 7.64*/** 16.11 ± 9.65** 14.10 ± 6.50 12.80 ± 7.19 32.36 ± 10.91** 25.00 ± 8.33** 17.63 ± 5.68** 14.12 ± 6.52
 Insomnia 22.06 ± 9.97 34.68 ± 10.55*/** 29.77 ± 7.99*/** 25.81 ± 10.21*/** 21.97 ± 10.97 24.24 ± 10.61 41.88 ± 12.90** 39.40 ± 11.96** 29.19 ± 9.47** 21.45 ± 12.74
 Appetite loss 36.01 ± 12.24 22.81 ± 12.74*/** 22.81 ± 13.07** 17.91 ± 9.43*/** 19.45 ± 8.78** 31.80 ± 19.17 27.06 ± 10.95** 23.99 ± 13.41** 22.33 ± 11.28** 21.07 ± 8.79**
 Constipation 22.11 ± 13.20 17.87 ± 11.58*/** 16.03(9.37–28.83) 17.44 ± 1.23** 16.20 ± 7.81** 17.40(8.39–26.69) 22.64 ± 12.1** 21.46(7.65–32.99) 18.88 ± 8.06 17.94 ± 9.23
EORTC OES 18
 Dysphagia 39.26 ± 17.21 26.15 ± 13.22** 23.80 ± 12.06** 22.66 ± 11.98** 17.29 ± 7.39** 39.86 ± 10.03 27.55 ± 15.03** 26.43 ± 12.16** 23.02 ± 12.56** 18.09 ± 8.73**
 Eating 39.57 ± 11.90 36.63(31.88–42.97) ** 32.12 ± 10.29** 24.66 ± 10.70** 22.81 ± 8.38** 39.00 ± 11.55 34.41 ± 11.57** 29.27 ± 14.67** 25.69 ± 12.28** 22.15 ± 9.75**
 Reflux 21.67 ± 10.37 37.58 ± 12.41** 33.31 ± 16.21** 32.05 ± 13.96** 29.57 ± 10.20** 22.23 ± 11.59 37.74 ± 17.40** 33.16 ± 15.51** 33.06 ± 13.78** 31.79 ± 15.02**
 Pain 16.55 ± 11.47 25.02 ± 10.00*/** 14.21 ± 7.93* 12.56 ± 7.12* 11.92 ± 6.14 18.24 ± 10.33 28.13 ± 10.80** 25.49 ± 11.92** 15.50 ± 9.48 12.27 ± 7.20**
 Choking 31.97 ± 14.17 23.08 ± 10.24** 22.87 ± 13.60** 21.60 ± 10.92*/** 21.17 ± 12.78** 31.33 ± 12.18 20.36 ± 12.74** 25.42 ± 14.50** 25.11 ± 9.80** 20.06 ± 10.48**
 Coughing 12.03(6.94–20.54) 27.51 ± 11.64** 25.96 ± 8.67** 21.52 ± 9.58** 19.93 ± 8.49** 14.32(4.79–22.67) 28.11 ± 14.80** 24.97 ± 8.07** 20.71 ± 8.37** 22.19 ± 10.64**
  1. aData are shown as number (%) and continuous data as mean standard deviation or median (interquartile range)
  2. bMeasures aspects of health and function; scores range from 0 to 100, with higher scores representing better well-being. Assesses aspects of oesophageal symptoms; scores range from 0 to 100, with lower scores indicating better function
  3. Every date was compared between groups and with the baseline within respective group, only p < 0.05 was notified:
  4. *MIILE compared with Sweet p < 0.05
  5. **compared with baseline p < 0.05
  6. EORTC European Organization for Research and Treatment of Cancer Quality of Life Questionnaires, MIILE minimally invasive Ivor Lewis esophagectomy