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Table 5 The associations between the TIMP-2 rs2277698 polymorphism and clinical characteristics of BC patients

From: Association between TIMP-2 gene polymorphism and breast cancer in Han Chinese women

Variants CC/TC/TT Allele model Genotype model Dominant model Recessive model Additive model
OR (95%CI) p TC genotype OR (95%CI) p TT genotype OR (95%CI) p OR (95%CI) p OR (95%CI) p OR (95%CI) p
c-erb
 Negative 126/76/11 1            
 Positive 66/23/2 1.72(1.08–2.74) 0.022 1.78(1.02–3.1) 0.043 2.88(0.62–13.4) 0.178 1.87(1.09–3.2) 0.023 2.4(0.52–11.08) 0.261 1.75(1.09–2.82) 0.021
ER
 Negative 76/28/4 1            
 Positive 124/74/9 1.43(0.93–2.19) 0.1 1.63(0.96–2.75) 0.069 1.38(0.41–4.63) 0.604 1.6(0.97–2.63) 0.068 1.18(0.36–3.94) 0.784 1.43(0.93–2.2) 0.102
PR
 Negative 102/39/4 1            
 Positive 95/61/9 1.63(1.09–2.43) 0.017 1.66(1.01–2.71) 0.045 2.42(0.72–8.14) 0.152 1.73(1.08–2.78) 0.024 2.06(0.62–6.85) 0.239 1.62(1.08–2.43) 0.021
Clinical stage
 I- II 175/86/11 1            
 III-IV 71/38/4 1.03(0.7–1.52) 0.874 1.09(0.5–2.35) 0.83 0.55(0.08–3.84) 0.542 1.01(0.48–2.13) 0.973 0.53(0.08–3.65) 0.518 0.94(0.5–1.76) 0.843
Menopausal status
 Premenopausal 64/34/6 1            
 Postmenopausal 99/51/6 0.89(0.58–1.37) 0.598 1.09(0.5–2.35) 0.83 0.55(0.08–3.84) 0.542 1.01(0.48–2.13) 0.973 0.53(0.08–3.65) 0.518 0.94(0.5–1.76) 0.843
Lymph node involvement
 Negative 129/64/8 1            
 Positive 127/61/7 0.96(0.67–1.36) 0.812 0.96(0.63–1.48) 0.861 0.9(0.32–2.55) 0.837 0.95(0.63–1.44) 0.827 0.91(0.32–2.56) 0.854 0.96(0.67–1.36) 0.803
≤49
 control 153/117/16 1            
 case 199/98/11 0.69(0.52–0.9) 0.007 0.66(0.47–0.93) 0.017 0.5(0.23–1.13) 0.095 0.64(0.46–0.89) 0.008 0.59(0.27–1.31) 0.193 0.68(0.51–0.9) 0.007
>49
 control 176/108/8 1            
 case 161/88/8 0.94(0.7–1.26) 0.684 0.89(0.62–1.27) 0.516 1.1(0.4–3) 0.852 0.9(0.64–1.28) 0.566 1.15(0.42–3.11) 0.785 0.94(0.69–1.27) 0.67
Procreative times
 ≥1 79/43/8 1            
 <1 64/37/3 0.89(0.57–1.38) 0.599 1.05(0.6–1.83) 0.869 0.48(0.12–1.93) 0.3 0.96(0.56–1.65) 0.889 0.47(0.12–1.87) 0.283 0.89(0.56–1.4) 0.611
Age of menarche
 >14 71/43/5 1            
 ≤14 93/45/7 0.89(0.59–1.36) 0.591 0.79 (0.47–1.33) 0.372 1.11(0.33–3.66) 0.868 0.82(0.5–1.36) 0.441 1.2(0.37–3.92) 0.76 0.89(0.59–1.36) 0.592
Tumor size
 ≥2 cm 70/31/4 1            
 <2 cm 90/56/8 1.34(0.86–2.07) 0.191 1.44(0.84–2.48) 0.189 1.5(0.43–5.25) 0.529 1.45(0.86–2.44) 0.166 1.32(0.38–4.56) 0.661 1.35(0.86–2.1) 0.188
  1. *p < 0.05 indicates statistical significance