Skip to main content

Table 5 The associations between the TIMP-2 rs2277698 polymorphism and clinical characteristics of BC patients

From: Association between TIMP-2 gene polymorphism and breast cancer in Han Chinese women

Variants

CC/TC/TT

Allele model

Genotype model

Dominant model

Recessive model

Additive model

OR (95%CI)

p

TC genotype OR (95%CI)

p

TT genotype OR (95%CI)

p

OR (95%CI)

p

OR (95%CI)

p

OR (95%CI)

p

c-erb

 Negative

126/76/11

1

           

 Positive

66/23/2

1.72(1.08–2.74)

0.022

1.78(1.02–3.1)

0.043

2.88(0.62–13.4)

0.178

1.87(1.09–3.2)

0.023

2.4(0.52–11.08)

0.261

1.75(1.09–2.82)

0.021

ER

 Negative

76/28/4

1

           

 Positive

124/74/9

1.43(0.93–2.19)

0.1

1.63(0.96–2.75)

0.069

1.38(0.41–4.63)

0.604

1.6(0.97–2.63)

0.068

1.18(0.36–3.94)

0.784

1.43(0.93–2.2)

0.102

PR

 Negative

102/39/4

1

           

 Positive

95/61/9

1.63(1.09–2.43)

0.017

1.66(1.01–2.71)

0.045

2.42(0.72–8.14)

0.152

1.73(1.08–2.78)

0.024

2.06(0.62–6.85)

0.239

1.62(1.08–2.43)

0.021

Clinical stage

 I- II

175/86/11

1

           

 III-IV

71/38/4

1.03(0.7–1.52)

0.874

1.09(0.5–2.35)

0.83

0.55(0.08–3.84)

0.542

1.01(0.48–2.13)

0.973

0.53(0.08–3.65)

0.518

0.94(0.5–1.76)

0.843

Menopausal status

 Premenopausal

64/34/6

1

           

 Postmenopausal

99/51/6

0.89(0.58–1.37)

0.598

1.09(0.5–2.35)

0.83

0.55(0.08–3.84)

0.542

1.01(0.48–2.13)

0.973

0.53(0.08–3.65)

0.518

0.94(0.5–1.76)

0.843

Lymph node involvement

 Negative

129/64/8

1

           

 Positive

127/61/7

0.96(0.67–1.36)

0.812

0.96(0.63–1.48)

0.861

0.9(0.32–2.55)

0.837

0.95(0.63–1.44)

0.827

0.91(0.32–2.56)

0.854

0.96(0.67–1.36)

0.803

≤49

 control

153/117/16

1

           

 case

199/98/11

0.69(0.52–0.9)

0.007

0.66(0.47–0.93)

0.017

0.5(0.23–1.13)

0.095

0.64(0.46–0.89)

0.008

0.59(0.27–1.31)

0.193

0.68(0.51–0.9)

0.007

>49

 control

176/108/8

1

           

 case

161/88/8

0.94(0.7–1.26)

0.684

0.89(0.62–1.27)

0.516

1.1(0.4–3)

0.852

0.9(0.64–1.28)

0.566

1.15(0.42–3.11)

0.785

0.94(0.69–1.27)

0.67

Procreative times

 ≥1

79/43/8

1

           

 <1

64/37/3

0.89(0.57–1.38)

0.599

1.05(0.6–1.83)

0.869

0.48(0.12–1.93)

0.3

0.96(0.56–1.65)

0.889

0.47(0.12–1.87)

0.283

0.89(0.56–1.4)

0.611

Age of menarche

 >14

71/43/5

1

           

 ≤14

93/45/7

0.89(0.59–1.36)

0.591

0.79 (0.47–1.33)

0.372

1.11(0.33–3.66)

0.868

0.82(0.5–1.36)

0.441

1.2(0.37–3.92)

0.76

0.89(0.59–1.36)

0.592

Tumor size

 ≥2 cm

70/31/4

1

           

 <2 cm

90/56/8

1.34(0.86–2.07)

0.191

1.44(0.84–2.48)

0.189

1.5(0.43–5.25)

0.529

1.45(0.86–2.44)

0.166

1.32(0.38–4.56)

0.661

1.35(0.86–2.1)

0.188

  1. *p < 0.05 indicates statistical significance
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us