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Table 4 TIMP-2 SNP genotypes and the risk of breast cancer based on the results of logistic regression model analysis

From: Association between TIMP-2 gene polymorphism and breast cancer in Han Chinese women

SNP Model Genotype Control Case OR (95%CI) p
rs2277698 Co-dominant CC 329 (56.9%) 361 (63.3%) 1 0.080
CT 225 (38.9%) 189 (33.2%) 0.77 (0.60–0.98)  
TT 24 (4.2%) 20 (3.5%) 0.72 (0.39–1.33)  
Dominant CC 329 (56.9%) 361 (63.3%) 1 0.025*
CT + TT 249 (43.1%) 209 (36.7%) 0.76 (0.60–0.97)  
Recessive CC + CT 554 (95.8%) 550 (96.5%) 1 0.460
TT 24 (4.2%) 20 (3.5%) 0.80 (0.43–1.46)  
Log-additive 0.80 (0.65–0.98) 0.029*
rs2009196 Co-dominant GG 184 (31.9%) 202 (35.4%) 1 0.190
CG 293 (50.9%) 290 (50.8%) 0.90 (0.69–1.16)  
CC 99 (17.2%) 79 (13.8%) 0.72 (0.50–1.03)  
Dominant GG 184 (31.9%) 202 (35.4%) 1 0.210
CG + CC 392 (68.1%) 369 (64.6%) 0.85 (0.67–1.09)  
Recessive GG + CG 477 (82.8%) 492 (86.2%) 1 0.100
C/C 99 (17.2%) 79 (13.8%) 0.76 (0.55–1.05)  
Log-additive 0.86 (0.72–1.02) 0.078
rs7342880 Co-dominant CC 419 (72.5%) 399 (69.9%) 1 0.470
AC 145 (25.1%) 160 (28.0%) 1.17 (0.90–1.52)  
AA 14 (2.4%) 12 (2.1%) 0.90 (0.41–1.97)  
Dominant CC 419 (72.5%) 399 (69.9%) 1 0.300
AC + AA 159 (27.5%) 172 (30.1%) 1.15 (0.89–1.48)  
Recessive CC + AC 564 (97.6) 559 (97.9) 1 0.710
AA 14 (2.4%) 12 (2.1%) 0.86 (0.39–1.88)  
Log-additive 1.10 (0.88–1.38) 0.410
rs4789936 Co-dominant CC 280 (48.4%) 280 (49.0%) 1 0.850
AC 241 (41.7%) 241 (42.2%) 1.00 (0.78–1.27)  
AA 57 (9.9%) 50 (8.8%) 0.89 (0.59–1.35)  
Dominant CC 280 (48.4%) 280 (49.0%) 1 0.840
AC + AA 298 (90.1%) 291 (51.0%) 0.98 (0.77–1.23)  
Recessive CC + AC 521 (90.1%) 521 (91.2%) 1 0.560
AA 57 (9.9%) 50 (8.8%) 0.89 (0.60–1.33)  
Log-additive 0.96 (0.81–1.15) 0.680
  1. SNP: single nucleotide polymorphism; OR: odds ratio; 95%CI: 95% confidence interval
  2. *p < 0.05 indicates statistical significance