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Table 5 Univariate and Multivariate Analysis of Covariables Associated with Lung Metastasis-Free Survival

From: Radiotherapy for inferior vena cava tumor thrombus in patients with hepatocellular carcinoma

Variable

Univariate analysis

Multivariate analysis

 

HR (95% CI)

P value

HR (95% CI)

P value

Age (< 65 vs. ≥65 years)

0.745 (0.344–1.617)

0.457

  

Gender (female vs. male)

0.664 (0.284–1.552)

0.344

  

ECOG performance status (2–3 vs. 0–1)

4.069 (1.665–9.943)

0.002

3.337 (0.895–12.440)

0.073

Child-Pugh class (B&C vs. A)

3.336 (1.475–7.543)

0.004

2.847 (0.867–9.354)

0.085

Right atrium invasion (yes vs. no)

2.134 (0.906–5.028)

0.083

  

Portal vein invasion (yes vs. no)

2.614 (1.109–6.162)

0.028

1.149 (0.406–3.250)

0.794

Hepatic vein invasion (yes vs. no)

0.973 (0.436–2.172)

0.947

  

LN metastasis (yes vs. no)

4.360 (1.415–13.429)

0.010

1.016 (0.248–4.171)

0.982

Systemic treatmenta (without vs. with)

3.263 (1.332–7.988)

0.010

2.463 (0.919–6.600)

0.073

RT dose (EQD10/2, Gy)b (<50 vs. ≥50)

2.171 (0.962–4.896)

0.062

  

Objective response of IVCc (no vs. yes)

3.471 (1.498–8.042)

0.004

5.732 (1.906–17.235)

0.002

  1. Abbreviations: ECOG Eastern Cooperative Oncology Group, LN lymph node, RT radiotherapy, IVC inferior vena cava
  2. aSystemic therapy given concurrently with and/or after RT.
  3. bEquivalent dose in 2 Gy fractions, α/β = 10
  4. cObjective response: complete and partial responses