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Table 4 Univariate and Multivariate Analysis of Covariables Associated with Overall Survival

From: Radiotherapy for inferior vena cava tumor thrombus in patients with hepatocellular carcinoma

Variable

Univariate analysis

Multivariate analysis

 

HR (95% CI)

P value

HR (95% CI)

P value

Age (< 65 vs. ≥65 years)

0.709 (0.350–1.434)

0.338

  

Gender (female vs. male)

0.748 (0.502–1.114)

0.153

  

ECOG performance status (2–3 vs. 0–1)

1.656 (1.138–2.410)

0.008

1.175 (0.365–3.776)

0.787

Child-Pugh class (B&C vs. A)

2.123 (1.472–3.062)

0.000

2.411 (1.073–5.414)

0.033

Right atrium invasion (yes vs. no)

1.330 (0.905–1.952)

0.146

  

Portal vein invasion (yes vs. no)

1.961 (1.343–2.864)

0.000

1.086 (0.662–1.782)

0.743

Hepatic vein invasion (yes vs. no)

0.970 (0.662–1.422)

0.876

  

LN metastasis (yes vs. no)

1.926 (1.232–3.010)

0.004

2.118 (1.171–3.831)

0.013

Lung metastasis (yes vs. no)

1.509 (1.000–2.276)

0.050

1.751 (1.064–2.883)

0.028

Systemic treatmenta (without vs. with)

2.430 (1.625–3.634)

0.000

1.346 (0.680–2.667)

0.394

RT dose (EQD10/2, Gy)b (<50 vs. ≥50)

1.583 (1.100–2.280)

0.013

1.050 (0.669–1.649)

0.832

Objective response of IVCc (no vs. yes)

2.326 (1.552–3.488)

0.000

2.604 (1.544–4.391)

0.000

  1. Abbreviations: ECOG Eastern Cooperative Oncology Group, LN lymph node, RT radiotherapy, IVC inferior vena cava
  2. aSystemic therapy given concurrently with and/or after RT.
  3. bEquivalent dose in 2 Gy fractions, α/β = 10
  4. cObjective response: complete and partial responses