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Table 3 Significant genetic associations between cardiorespiratory fitness and common variants

From: Identification of genetic association between cardiorespiratory fitness and the trainability genes in childhood acute lymphoblastic leukemia survivors

  Gene SNPs ID Minor Alleles Major Alleles p-value FDR MAF OR (95% CI) p-value* OR (95% CI)*
Affected Unaffected Affected Unaffected
N (%) N (%) N (%) N (%)
Survivors < 83.8% predicted \( \dot{\mathrm{V}} \) O2 peak TTN rs6723526 33 (14.47) 195 (85.53) 9 (4.55) 189 (95.45) 0.0005 0.04 0.1 3.55 (1.66–7.63) 0.0006 4.47 (1.89–10.53)
Female survivors < 83.8% predicted \( \dot{\mathrm{V}} \) O2 peak LEPR rs1137100 22 (17.19) 106 (82.81) 34 (37.78) 56 (62.22) 0.0008 0.03 0.25 0.34 (0.18–0.64) 0.003 0.33 (0.15–0.68)
IGFBP1 rs4619 43 (33.59) 85 (66.41) 51 (56.67) 39 (43.33) 0.0008 0.03 0.42 0.39 (0.22–0.67) 0.01 0.46(0.24–0.86)
ENO3 rs238239 41 (32.54) 85 (67.46) 46 (53.49) 40 (46.51) 0.002 0.05 0.4 0.42 (0.24–0.74) 0.005 0.34 (0.16–0.73)
  1. Threshold of FDR (false discovery rate) was 0.10. Affected were survivors who have a cardiorespiratory fitness level ≥ 83.8% and unaffected were survivors who have a cardiorespiratory fitness level < 83.8%. Results from genetic association were presented using allelic model, while results from adjusted logistic regression was presented using the genotypic model (i.e. additive)
  2. SNPs single-nucleotide polymorphisms, MAF Minor allele frequency, OR Odds Ratio
  3. *Logistic regression adjusted for age at visit, sex, cumulative doxorubicin dose and time from end of the treatment