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Table 3 Significant genetic associations between cardiorespiratory fitness and common variants

From: Identification of genetic association between cardiorespiratory fitness and the trainability genes in childhood acute lymphoblastic leukemia survivors

 

Gene

SNPs ID

Minor Alleles

Major Alleles

p-value

FDR

MAF

OR (95% CI)

p-value*

OR (95% CI)*

Affected

Unaffected

Affected

Unaffected

N (%)

N (%)

N (%)

N (%)

Survivors < 83.8% predicted \( \dot{\mathrm{V}} \) O2 peak

TTN

rs6723526

33 (14.47)

195 (85.53)

9 (4.55)

189 (95.45)

0.0005

0.04

0.1

3.55 (1.66–7.63)

0.0006

4.47 (1.89–10.53)

Female survivors < 83.8% predicted \( \dot{\mathrm{V}} \) O2 peak

LEPR

rs1137100

22 (17.19)

106 (82.81)

34 (37.78)

56 (62.22)

0.0008

0.03

0.25

0.34 (0.18–0.64)

0.003

0.33 (0.15–0.68)

IGFBP1

rs4619

43 (33.59)

85 (66.41)

51 (56.67)

39 (43.33)

0.0008

0.03

0.42

0.39 (0.22–0.67)

0.01

0.46(0.24–0.86)

ENO3

rs238239

41 (32.54)

85 (67.46)

46 (53.49)

40 (46.51)

0.002

0.05

0.4

0.42 (0.24–0.74)

0.005

0.34 (0.16–0.73)

  1. Threshold of FDR (false discovery rate) was 0.10. Affected were survivors who have a cardiorespiratory fitness level ≥ 83.8% and unaffected were survivors who have a cardiorespiratory fitness level < 83.8%. Results from genetic association were presented using allelic model, while results from adjusted logistic regression was presented using the genotypic model (i.e. additive)
  2. SNPs single-nucleotide polymorphisms, MAF Minor allele frequency, OR Odds Ratio
  3. *Logistic regression adjusted for age at visit, sex, cumulative doxorubicin dose and time from end of the treatment