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Table 2 Prediction model derivation to predict tumor response using IHC staining scores of selected molecular markers in training group (N = 63)

From: Prediction of response to pemetrexed in non-small-cell lung cancer with immunohistochemical phenotyping based on gene expression profiles

 

Univariable analysis

Optimized model

Odds ratio (95% CI)

P-value

Odds ratio (95% CI)

P-value

IHC score CPA3

1.82 (1.08–3.07)

0.025

  

IHC score EHZ2

0.47 (0.30–0.71)

< 0.001

0.56 (0.35–0.90)

0.015

IHC score TPX2

0.43 (0.26–0.70)

0.001

0.55 (0.30–1.01)

0.054*

IHC score MCM2

0.75 (0.0.59–0.96)

0.022

  

IHC score TOP2a

0.67 (0.51–0.88)

0.003

  
  1. *Model fit was significantly worse (based on difference − 2 Log Likelihood) if TPX2 was excluded. Abbreviations: CI confidence interval, EZH2 Enhancer of zeste homolog, TOP2A Topoisomerase II Alpha, TPX2 Microtubule Nucleation Factor, CPA3 Carboxypeptidase A3, MCM2 Minichromosome Maintenance Complex Component 2
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BMC Cancer

ISSN: 1471-2407

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