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Fig. 6 | BMC Cancer

Fig. 6

From: Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma

Fig. 6

CQ enhances the cancer suppression of ARHI in vivo. a Tumor volume changes in the four xenograft models. b Tumor weight of the four groups after different treatment. c Body weight changes of mouse models. d Dissected tumors from four xenograft models. e Immunohistochemistry of cleaved caspase-3, Ki67, Ras and ARHI in vivo. The scale bar represents 50 μm. (the bar whiskers represent SD, *p < 0.05, **p < 0.01, ***p < 0.001). f TEM photomicrographs of the four xenograft models. AVs, autophagic vacuoles; AVi, initial AVs (yellow arrows); AVd, late AVs (red arrows). The scale bar represents 2 μm

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