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Fig. 3 | BMC Cancer

Fig. 3

From: Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma

Fig. 3

ARHI can induce autophagy-mediated glioma cell death by inhibiting Ras/AKT/mTOR signaling. a-b Cell viability of LN229 and T98G cells after over-expressing ARHI or inhibiting autophagy by shATG5 (the bar whiskers represent SD, *p < 0.05, **p < 0.01, ***p < 0.001). c-d After transfecting LN229 and T98G cells with ARHI and negative control plasmids for 72 h, the expression levels of phosphorylated and total mTOR/ AKT were assessed by western blotting. e-f Using total mTOR and AKT as the internal controls, the expression levels of phosphorylated mTOR and AKT were calculated (the bar whiskers represent SD, *p < 0.05, **p < 0.01, ***p < 0.001)

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