Table 5 Multivariate survival analysis of polymorphisms in CRC patients
Genotype | CRC(n = 472) | Death(n = 85) | Adjusted HRa(95% CI) | P |
|---|---|---|---|---|
miR-130b rs373001T > C | ||||
 TT | 269 (57.0) | 47 (55.3) | 1.000 (reference) |  |
 TC | 168 (35.6) | 29 (34.1) | 0.810 (0.491–1.338) | 0.411 |
 CC | 35 (7.4) | 9 (10.6) | 1.345 (0.632–2.864) | 0.442 |
Dominant (TT vs TC + CC) |  | 0.910 (0.575–1.438) | 0.685 | |
Recessive (TT + TC vs CC) | 1.435 (0.688–2.990) | 0.336 | ||
miR-200b rs7549819T > C | ||||
 TT | 216 (45.7) | 48 (56.5) | 1.000 (reference) |  |
 TC | 200 (42.4) | 26 (30.6) | 0.522 (0.307–0.888) | 0.017 |
 CC | 56 (11.9) | 11 (12.9) | 0.781 (0.393–1.555) | 0.482 |
Dominant (TT vs TC + CC) |  | 0.592 (0.373–0.940) | 0.026 | |
Recessive (TT + TC vs CC) | 0.994 (0.509–1.944) | 0.987 | ||
miR-495 rs2281611A > C | ||||
 AA | 125 (26.5) | 23 (27.1) | 1.000 (reference) |  |
 AC | 222 (47.0) | 37 (43.5) | 1.077 (0.618–1.879) | 0.794 |
 CC | 125 (26.5) | 25 (29.4) | 1.167 (0.628–2.170) | 0.625 |
Dominant (AA vs AC + CC) |  | 1.126 (0.672–1.886) | 0.652 | |
Recessive (AA+AC vs CC) | 1.147 (0.691–1.903) | 0.595 | ||