Table 4 Combinatorial effects of miRNA polymorphisms and environmental factors on rectal cancer risk
Characteristics | miR-130bTT | miR-130bTC + CC | miR-200bTT | miR-200bTC + CC | miR-495AA + AC | miR-495CC |
|---|---|---|---|---|---|---|
AOR (95% CI) | AOR (95% CI) | AOR (95% CI) | AOR (95% CI) | AOR (95% CI) | AOR (95% CI) | |
Age | ||||||
  < 63 years | 1.000 (reference) | 1.222 (0.706–2.115) | 1.000 (reference) | 1.032 (0.599–1.780) | 1.000 (reference) | 1.563 (0.874–2.793) |
  ≥ 63 years | 1.097 (0.672–1.790) | 0.696 (0.412–1.176) | 0.826 (0.475–1.436) | 0.854 (0.515–1.415) | 1.107 (0.706–1.736) | 1.784 (1.038–3.064) |
Gender | ||||||
 Male | 1.000 (reference) | 0.799 (0.469–1.362) | 1.000 (reference) | 1.214 (0.707–2.085) | 1.000 (reference) | 1.772 (0.975–3.221) |
 Female | 1.087 (0.664–1.782) | 0.966 (0.570–1.636) | 1.454 (0.835–2.531) | 1.303 (0.753–2.255) | 0.885 (0.565–1.387) | 1.273 (0.730–2.222) |
Hypertension | ||||||
 No | 1.000 (reference) | 0.924 (0.531–1.610) | 1.000 (reference) | 0.799 (0.457–1.399) | 1.000 (reference) | 1.906 (1.050–3.461) |
 Yes | 2.539 (1.535–4.200) | 1.854 (1.076–3.196) | 1.921 (1.101–3.350) | 2.171 (1.279–3.683) | 2.362 (1.496–3.727) | 3.404 (1.902–6.092) |
Diabetes mellitus | ||||||
 No | 1.000 (reference) | 0.832 (0.544–1.274) | 1.000 (reference) | 0.872 (0.571–1.332) | 1.000 (reference) | 1.686 (1.077–2.642) |
 Yes | 2.535 (1.382–4.651) | 2.545 (1.385–4.676) | 1.946 (0.998–3.793) | 3.261 (1.798–5.913) | 3.088 (1.851–5.152) | 3.758 (1.685–8.383) |
Homocysteine (μmol/L) | ||||||
  < 13.3 | 1.000 (reference) | 0.795 (0.531–1.191) | 1.000 (reference) | 1.191 (0.794–1.787) | 1.000 (reference) | 1.641 (1.069–2.518) |
  ≥ 13.3 | 0.936 (0.451–1.943) | 1.199 (0.579–2.484) | 1.938 (0.904–4.152) | 0.820 (0.394–1.708) | 1.211 (0.653–2.248) | 1.619 (0.612–4.282) |
Folate (nmol/L) | ||||||
  > 3.7 | 1.000 (reference) | 0.853 (0.571–1.272) | 1.000 (reference) | 0.977 (0.654–1.458) | 1.000 (reference) | 1.478 (0.956–2.286) |
  ≤ 3.7 | 2.427 (1.152–5.114) | 2.193 (0.948–5.076) | 1.645 (0.685–3.953) | 2.512 (1.228–5.138) | 2.069 (1.016–4.216) | 3.829 (1.577–9.300) |
Triglyceride (mg/dL) | ||||||
  < 150 | 1.000 (reference) | 0.843 (0.545–1.303) | 1.000 (reference) | 0.902 (0.584–1.394) | 1.000 (reference) | 0.934 (0.567–1.538) |
  ≥ 150 | 0.524 (0.300–0.914) | 0.426 (0.227–0.799) | 0.373 (0.187–0.745) | 0.609 (0.352–1.055) | 0.457 (0.196–1.066) | 0.359 (0.179–0.718) |
HDL-C (mg/dL) | ||||||
  ≥ 40 | 1.000 (reference) | 0.839 (0.542–1.299) | 1.000 (reference) | 0.965 (0.624–1.492) | 1.000 (reference) | 1.119 (0.683–1.836) |
  < 40 | 2.706 (1.500–4.882) | 2.259 (1.162–4.394) | 2.575 (1.312–5.053) | 2.624 (1.442–4.775) | 4.639 (1.799–11.961) | 2.137 (1.141–4.001) |