Table 3 Genotype frequencies of microRNA polymorphisms in CRC subgroups and control subjects
Genotypes | Controls(n = 399) | Colon(n = 268) | AOR (95% CI) | P | FDR-P | Rectal(n = 193) | AOR (95% CI) | P | FDR-P |
|---|---|---|---|---|---|---|---|---|---|
miR-130b rs373001T > C | |||||||||
 TT | 216 (54.2) | 156 (58.2) | 1.000 (reference) |  | 109 (56.5) | 1.000 (reference) |  | ||
 TC | 157 (39.3) | 97 (36.2) | 0.830 (0.585–1.177) | 0.295 | 0.443 | 68 (35.2) | 0.812 (0.549–1.201) | 0.298 | 0.446 |
 CC | 26 (6.5) | 15 (5.6) | 0.671 (0.327–1.377) | 0.276 | 0.717 | 16 (8.3) | 1.061 (0.520–2.164) | 0.871 | 0.871 |
Dominant (TT vs TC + CC) |  | 0.805 (0.575–1.126) | 0.205 | 0.371 |  | 0.858 (0.593–1.241) | 0.415 | 0.908 | |
Recessive (TT + TC vs CC) | 0.740 (0.369–1.486) | 0.398 | 0.909 | 1.166 (0.583–2.331) | 0.664 | 0.664 | |||
miR-200b rs7549819T > C | |||||||||
 TT | 171 (42.9) | 126 (47.0) | 1.000 (reference) |  | 83 (43.0) | 1.000 (reference) |  | ||
 TC | 176 (44.1) | 109 (40.7) | 0.826 (0.580–1.177) | 0.290 | 0.443 | 88 (45.6) | 1.091 (0.740–1.608) | 0.660 | 0.660 |
 CC | 52 (13.0) | 33 (12.3) | 0.835 (0.493–1.412) | 0.500 | 0.717 | 22 (11.4) | 0.817 (0.449–1.488) | 0.509 | 0.764 |
Dominant (TT vs TC + CC) |  | 0.822 (0.589–1.146) | 0.248 | 0.371 |  | 1.022 (0.706–1.480) | 0.908 | 0.908 | |
Recessive (TT + TC vs CC) | 0.876 (0.531–1.447) | 0.606 | 0.909 | 0.775 (0.441–1.362) | 0.375 | 0.563 | |||
miR-495 rs2281611A > C | |||||||||
 AA | 103 (25.8) | 72 (26.9) | 1.000 (reference) |  | 51 (26.4) | 1.000 (reference) |  | ||
 AC | 194 (48.6) | 135 (50.4) | 0.881 (0.587–1.321) | 0.540 | 0.540 | 78 (40.4) | 0.744 (0.470–1.176) | 0.205 | 0.446 |
 CC | 102 (25.6) | 61 (22.8) | 0.919 (0.583–1.450) | 0.717 | 0.717 | 64 (33.2) | 1.319 (0.810–2.147) | 0.265 | 0.764 |
Dominant (AA vs AC + CC) |  | 0.900 (0.618–1.310) | 0.581 | 0.581 |  | 0.940 (0.621–1.421) | 0.768 | 0.908 | |
Recessive (AA+AC vs CC) | 0.991 (0.675–1.453) | 0.961 | 0.961 | 1.592 (1.071–2.368) | 0.022 | 0.065 | |||