Table 2 Genotype frequencies of microRNA polymorphisms in CRC patients and control subjects
Genotypes | Controls(n = 399) | Patients(n = 472) | AOR (95% CI) | P | FDR-P |
|---|---|---|---|---|---|
miR-130b rs373001T > C | |||||
 TT | 216 (54.2) | 269 (57.0) | 1.000 (reference) |  | |
 TC | 157 (39.3) | 168 (35.6) | 0.825 (0.610–1.115) | 0.210 | 0.416 |
 CC | 26 (6.5) | 35 (7.4) | 0.943 (0.532–1.670) | 0.840 | 0.840 |
Dominant (TT vs TC + CC) |  | 0.846 (0.635–1.127) | 0.254 | 0.398 | |
Recessive (TT + TC vs CC) | 1.028 (0.590–1.792) | 0.923 | 0.923 | ||
 HWE P | 0.723 | 0.222 |  | ||
miR-200b rs7549819T > C | |||||
 TT | 171 (42.9) | 216 (45.7) | 1.000 (reference) |  | |
 TC | 176 (44.1) | 200 (42.4) | 0.882 (0.652–1.194) | 0.416 | 0.416 |
 CC | 52 (13.0) | 56 (11.9) | 0.758 (0.481–1.194) | 0.232 | 0.696 |
Dominant (TT vs TC + CC) |  | 0.850 (0.638–1.132) | 0.266 | 0.398 | |
Recessive (TT + TC vs CC) | 0.789 (0.512–1.215) | 0.281 | 0.422 | ||
 HWE P | 0.527 | 0.356 |  | ||
miR-495 rs2281611A > C | |||||
 AA | 103 (25.8) | 125 (26.5) | 1.000 (reference) |  | |
 AC | 194 (48.6) | 222 (47.0) | 0.829 (0.584–1.176) | 0.292 | 0.416 |
 CC | 102 (25.6) | 125 (26.5) | 1.080 (0.734–1.590) | 0.696 | 0.840 |
Dominant (AA vs AC + CC) |  | 0.919 (0.666–1.268) | 0.608 | 0.608 | |
Recessive (AA+AC vs CC) | 1.208 (0.897–1.626) | 0.214 | 0.422 | ||
 HWE P | 0.582 | 0.197 |  | ||