Table 2 Demographic, clinicopathologic characteristics, and surgical margins status of the patients included in this study. NBI, narrow-band imaging; MM, macroscopic margin, AU, alcohol units; n.a., not available; RT, radiotherapy; CT, chemotherapy. When NBI and MM were overlapping, only one biopsy was performed
Case | Age (range) | Smoking | Alcohol | Site | Piazza et al. Classification [23] | Staging TNM | Grading | Lympho-vascular/Perineural invasion | Sample 1 NBI/MM | Sample 2 NBI/ MM | Sample 3 NBI/ MM | Sample 4 NBI/ MM | Adjuvant Therapy |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 50–60 | No | Yes (2 AU/die) | Lateral Tongue | 2b | T1Nx | G2 | No/No | – | −/− | – | – | No |
2 | 70–80 | Ex | Yes (2 AU/die) | Floor of mouth | 2a | T2 N0 | G2 | No/Yes | −/− | – | n.a. | n.a. | RT |
3 | 50–60 | Yes | Yes (2 AU/die) | Ventral Tongue | 2a | T2 N0 | G2 | No/Yes | −/− | −/− | n.a. | n.a. | RT |
4 | 50–60 | Ex | Yes (1 AU/die) | Floor of mouth | 2a | T1(m)Nx | n.a. | No/No | +/− | −/− | −/− | n.a. | CT + RT |
5 | 50–60 | Ex | Yes (1 AU/die) | Maxilla/Alveolar Mucosa | 1 | T4aNx | G1 | No/No | −/− | −/− | n.a. | n.a. | No |
6 | > 80 | No | Yes (1 AU/die) | Mandible/Alveolar Mucosa | 1 | T4aN0 | G1 | No/No | −/− | −/− | −/− | −/− | No |
7 | 60–70 | Ex | Yes (1 AU/die) | Lateral Tongue | 2b | T1 N1(E-)R1 | G2 | No/No | n.a. | −/− | – | −/+ | CT + RT |
8 | > 80 | No | No | Cheek | 2b | T2N1R0 | G2 | No/Yes | n.a. | −/+ | −/− | – | No |
9 | > 80 | No | Ex Drinker | Hard Palate | 1 | T4aN2b (E-) R0 | G2 | No/No | – | – | – | −/− | No |
10 | 70–80 | Ex | No | Mandible/Retromolar Trigone | 2b | T2 N1 (E-) R0 | G3 | No/No | +/− | – | −/− | −/− | RT |
11 | < 30 | Ex | Yes (1 AU/die) | Lateral Tongue | 2b | T2N2b | G2 | No/Yes | +/+ | −/− | + | −/− | CT + RT |
12 | 60–70 | Ex | Yes (1 AU/die) | Mandible/Alveolar Mucosa | 1 | T2 N0R0 | G2 | No/Yes | – | −/− | – | – | No |
13 | > 80 | Yes | No | Lateral Tongue | 2b | T1N2b | G2 | No/No | – | – | – | −/+ | No |
14 | > 80 | Ex | Yes (1 AU/die) | Cheek | 2b | T1 N0 | G2 | No/No | + | −/− | −/− | −/− | No |
15 | 70–80 | Ex | Yes (1 AU/die) | Hard Palate | 1 | T4aN0 | G2 | No/No | – | −/− | −/− | −/− | No |
16 | 50–60 | Yes | Yes (1 AU/die) | Floor of mouth | 2a | T1 N0 | G2 | No/No | – | −/− | n.a. | −/− | No |