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Table 2 Demographic, clinicopathologic characteristics, and surgical margins status of the patients included in this study. NBI, narrow-band imaging; MM, macroscopic margin, AU, alcohol units; n.a., not available; RT, radiotherapy; CT, chemotherapy. When NBI and MM were overlapping, only one biopsy was performed

From: A novel integrated platform for the identification of surgical margins in oral squamous cell carcinoma: results from a prospective single-institution series

Case Age (range) Smoking Alcohol Site Piazza et al. Classification [23] Staging TNM Grading Lympho-vascular/Perineural invasion Sample 1 NBI/MM Sample 2 NBI/ MM Sample 3 NBI/ MM Sample 4 NBI/ MM Adjuvant Therapy
1 50–60 No Yes (2 AU/die) Lateral Tongue 2b T1Nx G2 No/No −/− No
2 70–80 Ex Yes (2 AU/die) Floor of mouth 2a T2 N0 G2 No/Yes −/− n.a. n.a. RT
3 50–60 Yes Yes (2 AU/die) Ventral Tongue 2a T2 N0 G2 No/Yes −/− −/− n.a. n.a. RT
4 50–60 Ex Yes (1 AU/die) Floor of mouth 2a T1(m)Nx n.a. No/No +/− −/− −/− n.a. CT + RT
5 50–60 Ex Yes (1 AU/die) Maxilla/Alveolar Mucosa 1 T4aNx G1 No/No −/− −/− n.a. n.a. No
6 > 80 No Yes (1 AU/die) Mandible/Alveolar Mucosa 1 T4aN0 G1 No/No −/− −/− −/− −/− No
7 60–70 Ex Yes (1 AU/die) Lateral Tongue 2b T1 N1(E-)R1 G2 No/No n.a. −/− −/+ CT + RT
8 > 80 No No Cheek 2b T2N1R0 G2 No/Yes n.a. −/+ −/− No
9 > 80 No Ex Drinker Hard Palate 1 T4aN2b (E-) R0 G2 No/No −/− No
10 70–80 Ex No Mandible/Retromolar Trigone 2b T2 N1 (E-) R0 G3 No/No +/− −/− −/− RT
11 < 30 Ex Yes (1 AU/die) Lateral Tongue 2b T2N2b G2 No/Yes +/+ −/− + −/− CT + RT
12 60–70 Ex Yes (1 AU/die) Mandible/Alveolar Mucosa 1 T2 N0R0 G2 No/Yes −/− No
13 > 80 Yes No Lateral Tongue 2b T1N2b G2 No/No −/+ No
14 > 80 Ex Yes (1 AU/die) Cheek 2b T1 N0 G2 No/No + −/− −/− −/− No
15 70–80 Ex Yes (1 AU/die) Hard Palate 1 T4aN0 G2 No/No −/− −/− −/− No
16 50–60 Yes Yes (1 AU/die) Floor of mouth 2a T1 N0 G2 No/No −/− n.a. −/− No