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Table 6 Univariate and Multivariate Logistic Regression Predictors of Skipping Mediastinal lymph Node Metastasis

From: Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancer

Independents Variables

Univariate Predictors

Multivariate Predictors

N Metastasis/N total

Odds Ratio (95% CI), P-value

B

Odds Ratio (95% CI), P-value

Age (years)

 ≤60

8/298 (2.7%)

Reference

 

 > 60

3/291 (0%)

0.38 (0.10–1.44), 0.153*

Sex

 Female

8/301 (2.7%)

Reference

 

 Male

3/288 (1.0%)

0.39 (0.10–1.47), 0.162*

Maximum diameter of tumor

 ≤1.6 cm

6/303 (2.0%)

Reference

 

 > 1.6 cm

4/279 (1.4%)

0.72 (0.20–2.58), 0.614

Position

0.961

 Right Upper Lobe

4/181 (2.2%)

Reference

 Right Middle Lobe

0/28 (0.0%)

0.00 (0.00,), 0.998

 Right Lower Lobe

3/84 (3.6%)

1.64 (0.36–7.49), 0.524

 Left Upper Lobe

2/135 (1.5%)

0.67 (0.12–3.69), 0.641

 Left Lower Lobe

1/87 (1.1%)

0.52 (0.06–4.67), 0.555

 Ipsilateral Mixed lobes

1/48 (2.1%)

0.94 (0.10–8.62), 0.957

 Bilateral Mixed lobes

0/26 (0.0%)

0.00 (0.00,), 0.998

Pathological type

 Adenocarcinoma

7/440 (1.6%)

Reference

 

 Others

4/147 (2.75)

1.73 (0.50–6.00), 0.387

Tumor differentiation

 No

2/153 (1.3%)

Reference

 

 Yes

9/413 (2.2%)

1.68 (0.36–7.87), 0.509

Pathological morphology

 No

4/209 (1.9%)

Reference

 

 Yes

7/356 (2.0%)

1.03 (0.30–3.55), 0.965

Pulmonary membrane invasion

 No

8/427 (1.9%)

Reference

 

 Yes

2/57 (3.5%)

1.91 (0.39–9.20), 0.423

Bronchial mucosa and cartilage invasion

 No

10/534 (1.9%)

Reference

 

 Yes

1/54 (1.9%)

0.99 (0.12–7.87), 0.991

Vascular invasion

 No

10/542 (1.8%)

Reference

 

 Yes

1/44 (2.3%)

1.24 (0.16–9.89), 0.841

Nerve invasion

 No

9/576 (1.6%)

Reference

 

 Yes

2/12 (16.7%)

12.60 (2.41–65.93), 0.003*

3.37

29.11 (3.81–222.61), 0.001#

CEA

 ≤2.21 ng/ml

6/250 (2.4%)

Reference

 

 > 2.21 ng/ml

5/253 (2.0%)

0.82 (0.25–2.72), 0.746

Albumin

 ≤43.1 g/l

3/287 (1.0%)

Reference

 

 > 43.1 g/l

8/286 (2.8%)

0.34 (0.19–0.62), < 0.0001*

1.63

5.09 (0.99–26.20), 0.051#

  1. *Only variables with P value less than 0.20 were included in the multivariate analysis. # P < 0.05 Sum might not always be in total because of missing data