Table 4 Univariate and Multivariate Logistic Regression Predictors of Lobe specific Mediastinal lymph Node Metastasis
Independents Variables | Univariate Predictors | Multivariate Predictors | ||
|---|---|---|---|---|
N Metastasis/N total | Odds Ratio (95% CI), P-value | B | Odds Ratio (95% CI), P-value | |
Age (years) | ||||
≤60 | 25/298 (8.4%) | Reference | ||
> 60 | 25/291 (8.6%) | 1.03 (0.58–1.83), 0.930 | ||
Sex | ||||
Female | 18/301 (6.0%) | Reference | ||
Male | 32/288 (11.1%) | 1.97 (1.08–3.59), 0.028* | ||
Maximum diameter of tumor | ||||
≤1.6 cm | 10/303 (3.3%) | Reference | ||
> 1.6 cm | 39/279 (14.0%) | 4.76 (2.33–9.74), < 0.0001* | 1.16 | 3.18 (1.15–8.78), 0.026# |
Position | 0.096* | 0.019# | ||
Right Upper Lobe | 9/181 (5.0%) | Reference | ||
Right Middle Lobe | 4/28 (14.3%) | 3.19 (0.91–11.15), 0.070* | 1.78 | 5.92 (0.93–37.66), 0.060 |
Right Lower Lobe | 14/84 (16.7%) | 3.82 (1.58–9.24), 0.003* | 2.42 | 11.29 (2.50–51.04), 0.002# |
Left Upper Lobe | 10/135 (7.4%) | 1.53 (0.60–3.87), 0.371 | 0.06 | 1.07 (0.22–5.07), 0.937 |
Left Lower Lobe | 7/87 (8.0%) | 1.67 (0.60–4.65), 0.324 | 1.21 | 3.35 (0.78–14.38),0.103 |
Ipsilateral Mixed lobes | 4/48 (8.3%) | 1.74 (0.51–5.91), 0.376 | 1.93 | 6.89 (1.16–40.83),0.034# |
Bilateral Mixed lobes | 2/26 (7.7%) | 1.59 (0.33–7.81), 0.566 | 2.54 | 12.69 (1.65–97.51),0.015# |
Pathological type | ||||
Adenocarcinoma | 41/440 (9.3%) | Reference | ||
Others | 9/147 (6.1%) | 0.64 (0.30–1.34), 0.233 | ||
Tumor differentiation | ||||
No | 2/153 (1.3%) | Reference | ||
Yes | 48/413 (11.6%) | 9.93 (2.38–41.37), 0.002* | ||
Pathological morphology | ||||
No | 16/209 (7.7%) | Reference | ||
Yes | 33/356 (9.3%) | 1.23 (0.66–2.30), 0.511 | ||
Pulmonary membrane invasion | ||||
No | 27/427 (6.3%) | Reference | ||
Yes | 12/57 (21.1%) | 3.95 (1.87–8.34), < 0.0001* | 1.53 | 4.60 (1.60–13.23),0.005# |
Bronchial mucosa and cartilage invasion | ||||
No | 36/534 (6.7%) | Reference | ||
Yes | 14/54 (25.9%) | 4.84 (2.41–9.71), < 0.0001* | ||
Vascular invasion | ||||
No | 35/542 (6.5%) | Reference | ||
Yes | 15/44 (34.1%) | 7.49 (3.68–15.26), < 0.0001* | 1.35 | 3.85 (1.26–11.78), 0.018# |
Nerve invasion | ||||
No | 47/576 (8.2%) | Reference | ||
Yes | 3/12 (25.0%) | 3.75 (0.98–14.33), 0.053* | ||
CEA | ||||
≤2.21 ng/ml | 6/250 (2.4%) | Reference | ||
> 2.21 ng/ml | 35/253 (13.8%) | 6.53 (2.69–15.82), < 0.0001* | 1.79 | 6.01 (1.86–19.44), 0.003# |
Albumin | ||||
≤43.1 g/l | 33/287 (11.5%) | Reference | ||
> 43.1 g/l | 16/286 (5.6%) | 0.46 (0.25–0.85), 0.013* | ||