Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer

Table 3 IHC expression of minichromosome maintenance protein 6 and correlation to the patients´ outcome

	N	OS [months]			DFS [months]
		expression			expression
		> 85%	≤85%	p	> 85%	≤85%	p
all	570	n.a.	87.0	0.008	n.a.	51.0	0.001
age (years)
< 65	270	n.a.	136.0	0.007	n.a.	n.a.	0.418
≥ 65	280	82.0	51.9	0.246	n.a.	n.a.	0.419
tumor site
right colon	162	104.3	49.8	0.026	n.a.	n.a.	0.135
left colon + rectum	385	n.a.	110.1	0.086	n.a.	n.a.	0.658
UICC
I + II	262	154.6	154.6	0.745	n.a.	n.a.	0.965
III	184	84.0	84.0	0.414	n.a.	n.a.	0.373
IV	101	16.4	16.4	0.199	13.6	21.5	0.423
histological grading
I	9	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.
II	448	n.a.	104.9	0.008	n.a.	n.a.	0.149
III	92	104.3	33.7	0.393	n.a.	n.a.	0.839
histology
adeno carcinoma	466	n.a.	104.9	0.026	n.a.	n.a.	0.837
mucinous + signet-ring carcinoma	75	11.3	41.9	0.103	n.a.	34.7	0.006
resection margin
R0	509	n.a.	130.5	0.115	n.a.	n.a.	0.244
R1 + R2	29	11,3	15.3	0.308	9,7	n.a.	0.001

All P values in bold, are regarded as statistically significant. Abbreviations: UICC – Union internationale contre le cancer; n.a. – not achieved

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