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Table 3 VEGAS2 gene-level analysis of the additive TTT and OS models. Genes with a BH-adjusted P-value < 0.1 are shown

From: The association of germline variants with chronic lymphocytic leukemia outcome suggests the implication of novel genes and pathways in clinical evolution

Gene nSNPs nSims Test P value TopSNP TopSNP.p value BH-ajdusted p-value
VEGAS2 Analysis of TTT
AURKAIP1 2 1.00E+06 26.72 1.00E-06 rs2765035 2.28E-04 6.90E-03
NIFK 4 1.00E+06 36.22 1.00E-06 rs17016977 5.69E-06 6.90E-03
RIPK3 7 1.00E+06 22.32 2.00E-06 rs28379107 0.02 9.20E-03
SIK1 3 1.00E+06 31.07 9.00E-06 rs3746951 2.32E-05 0.03
ZCCHC7 2 1.00E+06 23.2 1.10E-05 rs3780333 3.84E-06 0.03
ABCA7 18 1.00E+06 88.04 2.30E-05 rs3752230 3.22E-04 0.05
PEX26 7 1.00E+06 83.49 2.70E-05 rs361807 4.31E-07 0.05
AARS 3 1.00E+06 17.21 4.10E-05 rs2070203 2.34E-03 0.06
NIFK-AS1 3 1.00E+06 24.72 4.50E-05 rs17016977 5.69E-06 0.06
TSPO 2 1.00E+06 24.36 4.60E-05 rs6971 7.18E-05 0.06
MARCH.10 2 1.00E+06 20.45 4.80E-05 rs72842201 6.13E-06 0.06
LOC574538 3 1.00E+06 24.15 7.20E-05 rs56204927 1.94E-04 0.08
SEC24D 10 1.00E+06 44.69 7.60E-05 rs115446044 1.09E-03 0.08
TTLL12 9 1.00E+06 54.06 9.90E-05 rs9463 3.11E-06 0.1
GALNT11 4 1.00E+06 15.18 1.07E-04 rs146169444 0.01 0.1
VEGAS2 Analysis of OS
CLUAP1 7 1.00E+06 57.76 1.00E-06 rs78851263 3.27E-04 6.17E-03
TTC32 5 1.00E+06 66.51 1.00E-06 rs2304588 7.36E-07 6.17E-03
DRD3 2 1.00E+06 21.54 4.00E-06 rs3732783 9.77E-06 0.02
RAD51AP2 7 1.00E+06 22.31 6.00E-06 rs62130401 0.02 0.02
RIPK3 8 1.00E+06 18.64 1.30E-05 rs3212251 0.01 0.03
EPYC 2 1.00E+06 17.78 2.00E-05 rs76171854 3.25E-04 0.03
TENM4 13 1.00E+06 75.05 2.10E-05 rs1790557 1.16E-05 0.03
GTPBP1 6 1.00E+06 17.81 2.30E-05 rs16999297 6.42E-03 0.03
GAMT 2 1.00E+06 17.56 2.80E-05 rs266809 8.65E-05 0.03
DCP1B 16 1.00E+06 61.9 3.00E-05 rs150660202 7.13E-03 0.03
MIR548D1 3 1.00E+06 17.35 3.30E-05 rs12141159 4.48E-04 0.03
MIR548AA1 3 1.00E+06 17.35 3.40E-05 rs12141159 4.48E-04 0.03
WDR35 14 1.00E+06 89.29 5.90E-05 rs2293671 1.43E-06 0.06
BNIPL 6 1.00E+06 23.11 7.40E-05 rs955955 2.91E-03 0.06
KARS 3 1.00E+06 15.43 1.05E-04 rs148298278 1.28E-04 0.09
ACO1 13 1.00E+06 57.84 1.26E-04 rs56127964 3.88E-06 0.1
PARP6 3 1.00E+06 21.16 1.33E-04 rs76774695 7.96E-06 0.1