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Table 4 Review of the response to platinum retreatment in patients who were tested with tNGS (11 cases) and OncoScan® FFPE platform (15 cases)

From: Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes

ID

Pre-treatment CA125

Post-treatment

CA125

CA125 Confirmation

Largest lesion pre -treatment

Largest lesion post-treatment

Treatment Response

1

102.9

32.2

SUV 4.54 in pelvis

No PET-CT contrast enhancement

CR

2

115

62

31

Pleural (72 mm)

Pleural (70 mm)

PR

3

40.9

20.1

17.1

Peritoneal (31 mm)

Peritonium (26 mm)

SD

4

637

1143

Liver (45 mm)

Liver (54 mm)

DP

5

92.3

79

24.2

Peritoneal (63 mm)

Peritonium

(47 mm)

PR

6

35

18.6

0

SUV 11.0 in liver, 3.2 in adrenal, 8.0 pre-sacral

No PET-CT contrast enhancement

CR

7

1174

222,9

71.5

Pleural effusion

Pleural effusion resolution*

PR

8

258

331

SUV 3.0 in peritoneal lesion, 1.9 in epiplon, 3.0 in gut

SUV 11.6 in peritoneal lesion, 3.7 in epiplon, 9.5 in gut

DP

9

Bowel obstruction

DP

10

4430

1887

2180

Pelvic (101 mm)

Pelvic (90 mm)

PR

11

546

81.6

60

Pre-sacral (117 mm)

Pre-sacral

(106 mm)

PR

12

2600

3004

Peritoneal thickening

New hepatic lesion (24 mm)

DP

13

32

14.2

17.6

Retroperitoneal lesion (40 mm)

Retroperitoneal lesion (40 mm)

SD

14

Bowel obstruction

DP

15

52.2

94.6

185

New brain lesion

DP

  1. CA125 confirmation: a second CA125 measurement at least two weeks after the post treatment was performed aiming to confirm the treatment response; PET-CT FDG positron emission tomography – compute tomography, SUV standardized uptake value, CR complete response, PR partial response, SD stable disease, DP disease progression
  2. *No surgical procedure was performed between the evaluations