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Table 3 Homologous Recombination Deficiency (HRD) scores evaluated in 15 high grade ovarian cancer samples

From: Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes

ID

tAI

LOH

LST

CS

1

11

4

15

30

2

13

5

10

28

3

15

3

9

27

4

36

25

22

83

5

48

28

28

104

6a

39

15

30

84

7a

33

22

32

87

8a

12

5

13

30

9

35

14

28

77

10

40

19

26

85

11

15

0

28

43

12

15

6

9

30

13

31

9

24

64

14

8

4

5

17

15a

33

16

29

78

Median (P25–75)

31.0 (13–36)

9.0 (4–19)

24.0 (10–28)

64 (30–84)

  1. tAI elomeric allellic imbalance score, LOH loss of heterozygosity score, LST large scale transition score, CS composite score, P25–75 interquartile range. The cut-off values were the median 30 for tAI, > 10 for LOH, > 42 for CS and > 15 for near-diploid tumors or > 20 for near-tetraploid tumors for LST scores
  2. aBRCA1 mutated
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BMC Cancer

ISSN: 1471-2407

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