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Table 2 Clinical features, response to platinum retreatment and molecular findings of 15 ovarian cancer patientsa

From: Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes

ID Histology Response HRD TP53 BRCA1 BRCA2 Other Mutations Family History CCNE CN RB1 CN
1 HGSC CR No c.782 + 1G > A WT WT WT Yes 2.3 1.9
2 HGSC PR No WT WT WT WT No 2.9 1.8
3 HGSC SD No c.672 + 1G > T WT WT XRCC2 c.643C > T
APC c136G > T
Yes 4.0 1.9
4 HGSC SD Yes nd nd nd nd No 2.1 2.0
5 HGSC PR Yes c.734G > A WT WT WT No 1.9 1.1
6 HGSC CR Yes WT c.415C > A WT MUTYH c.991G > T No 1.5 1.5
7 UC PR Yes c.245delC c.5044G > T c.8350C > T WT Yes 2.0 3.0
8 UC DP No WT c.3931_3934delAACA WT WT Yes 2.3 1.9
9 HGSC DP Yes nd nd nd nd Yes 2.6 1.1
10 HGSC PR Yes c.536A > G
c.4G > T
WT WT POLE c.4111C > T No 1.5 1.2
11 HGSC PR Yes c.920-2A > T WT WT APC c.5758C > T
c.6610C > T
Yes 2.0 1.5
12 HGSC DP No c.718delA WT WT XRCC2 c.110C > A No 3.5 3.2
13 HGSC SD No nd nd nd nd No 1.7 1.8
14 HGSC DP Yes nd nd nd nd No 2.4 2.0
15 HGE DP Yes c.524G > A c.5096G > A WT WT No 2.2 1.1
  1. aTarget-next generation sequencing was performed in 11 of 15 cases. HRD homologous recombination deficiency, CN copy number, HGSC high grade serous carcinoma, UC undifferentiated carcinoma, HGE high grade endometrioid carcinoma, CR complete response, PR partial response, SD stable disease, DP disease progression, nd not determined, WT wild type alleles. Copy number gain was defined as CN > 2.0; copy number loss was defined as CN < 2.0. HRD was considered with CS score ≥ 42