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Table 4 Clinicopathological characteristics of patients with adjuvant chemotherapy

From: Body weight loss after surgery affects the continuity of adjuvant chemotherapy for pancreatic cancer

 

RDI ≥ 80%

RDI < 80%

p

N = 11

N = 28

 

Age (mean ± SD)

63.4 ± 8.0

72.5 ± 6.1

< 0.001

Age ≥ 75 (Y: N)

0: 11

11: 17

0.017

Sex (Male: Female)

5: 6

12: 16

N.S.

Comorbidity (Y: N)

6: 5

21: 7

N.S.

Operative method (PD: DP)

7: 4

21: 7

N.S.

Extended dissection of nerve plexus around SMA (Y: N)a

2: 9

10: 18

N.S.

Postoperative diarrhea (Y: N)

3: 8

10: 18

N.S.

Postoperative pancreatic fistula grade B or C

3: 8

8: 20

N.S.

Postoperative delayed gastric emptying (Y: N)

3: 8

4: 24

N.S.

Regimen (GEM: S-1: Both)

3: 6: 2

5: 20: 3

N.S.

Postoperative blood test

 WBC (/μl)

5238 ± 1588

5784 ± 1376

N.S.

 Neutrophil

3528 ± 1333

3860 ± 1135

N.S.

 Hg (g/dl)

11.2 ± 1.4

10.7 ± 1.1

N.S.

 PLT (*104/μl)

35.5 ± 11.7

32.5 ± 12.5

N.S.

 AST (IU/l)

43.2 ± 23.0

35.1 ± 19.4

N.S.

 ALT (IU/l)

65.9 ± 57.8

39.1 ± 30.0

N.S.

 BUN (mg/dl)

12.6 ± 6.1

11.1 ± 3.1

N.S.

 Cre (mg/dl)

0.65 ± 0.24

0.67 ± 0.20

N.S.

 CCr (ml/min)

75.2 ± 25.1

62.2 ± 17.5

N.S.

 Albumin (g/dl)

3.4 ± 0.3

3.1 ± 0.4

N.S.

 Albumin maintenance rate ≥ 90% (Y: N)b

3: 8

6: 22

N.S.

 BWL ≥10% (Y: N)c

2: 9

16: 12

0.037

  1. aExtended dissection of nerve plexus around SMA was defined as more than a half
  2. bAlbumin maintenance rate was defined as: % albumin maintenance = albumin value at the time of discharge / preoperative albumin value × 100
  3. cBWL (body weight loss): % body weight loss = (preoperative body weight – body weight at the time of discharge) × 100 / preoperative body weight
  4. Boldface indicates the statistical significance