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2 Correlations between liver cirrhosis and clinicopathological features of HCC patients

From: Paracrine effects of CCN3 from non-cancerous hepatic cells increase signaling and progression of hepatocellular carcinoma

Variable Patients with Cirrhosis (N = 374)
yes no p
Age, y
  ≥ 50 171 16 0.101
  < 50 161 26  
HBsAg
 Positive 318 29 <0.001
 Negative 14 13  
Serum, AFP (μg/L)
  ≥ 20 216 20 0.026
  < 20 116 22  
Tumor dimension
  ≥ 5 cm 62 19 <0.001
  < 5 cm 270 23  
Vascular invasion
 Yes 100 14 0.679
 No 232 28  
Tumor differentiation
 I-II 253 27 0.096
 III-IV 79 15  
Sex
 Male 271 35 0.823
 Female 60 7  
Serum, ALT (IU/L)
  ≥ 60 34 6 0.389
  < 60 298 36  
No. of tumors
 Multiple 19 0 0.242*
 Single 313 42  
Tumor encapsulation
 Complete 196 20 0.152
 None 136 22  
Tumor recurrence
 Yes 165 16 0.162
 No 167 26  
  1. AFP, alpha-fetoprotein; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus
  2. *Fisher’s exact test