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Fig. 3 | BMC Cancer

Fig. 3

From: Paracrine effects of CCN3 from non-cancerous hepatic cells increase signaling and progression of hepatocellular carcinoma

Fig. 3

CCN3 from hepatic cells increases HCC growth and migration and induces MAPK signaling and EMT. Hep3B cells treated with LO2-CM exhibit significantly increased migration (a, a) and invasion (a, b). Hep3B proliferation is increased by LO2-CM (b). Endogenous CCN3 expression is significantly downregulated in aLO2 by lentiviral shRNA, as shown by Western blotting (c) and ELISA (d). MAPK signaling and EMT are induced in Hep3B treated with LO2-CM, as demonstrated by increased p-RAF, p-MEK, p-ERK, and Vimentin and reduced E-cadherin (e). Recombinant CCN3 induces this same trend in MAPK signaling activation and EMT (f). aLO2-CCN3sh1-CM inhibits MAPK signaling and EMT compared with aLO2-CM in HCC cells (g)

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BMC Cancer

ISSN: 1471-2407

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